Names & Taxonomy
- Uniprot ID:
- P01023
- Entry Name:
- A2MG_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5)
- Gene Names:
- A2M CPAMD5 FWP007
- Gene Names Orf:
- FWP007
- Gene Names Primary:
- A2M
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1474
- Sequence:
- MGKNKLLHPSLVLLLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLESVRGNRSLFTDLEAENDVLHCVAFAVPKSSSNEEVMFLTVQVKGPTQEFKKRTTVMVKNEDSLVFVQTDKSIYKPGQTVKFRVVSMDENFHPLNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQGSYKVVVQKKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHGEDSQAFCEKFSGQLNSHGCFYQQVKTKVFQLKRKEYEMKLHTEAQIQEEGTVVELTGRQSSEITRTITKLSFVKVDSHFRQGIPFFGQVRLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSINTTNVMGTSLTVRVNYKDRSPCYGYQWVSEEHEEAHHTAYLVFSPSKSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGLKKLSFYYLIMAKGGIVRTGTHGLLVKQEDMKGHFSISIPVKSDIAPVARLLIYAVLPTGDVIGDSAKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDQSVLLMKPDAELSASSVYNLLPEKDLTGFPGPLNDQDNEDCINRHNVYINGITYTPVSSTNEKDMYSFLEDMGLKAFTNSKIRKPKMCPQLQQYEMHGPEGLRVGFYESDVMGRGHARLVHVEEPHTETVRKYFPETWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTASLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAFLAVPVEKEQAPHCICANGRQTVSWAVTPKSLGNVNFTVSAEALESQELCGTEVPSVPEHGRKDTVIKPLLVEPEGLEKETTFNSLLCPSGGEVSEELSLKLPPNVVEESARASVSVLGDILGSAMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARAYIFIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVTHPVVRNALFCLESAWKTAQEGDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKDNSVHWERPQKPKAPVGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVKWITKQQNAQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLLQQVSLPELPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFPFALGVQTLPQTCDEPKAHTSFQISLSVSYTGSRSASNMAIVDVKMVSGFIPLKPTVKMLERSNHVSRTEVSSNHVLIYLDKVSNQTLSLFFTVLQDVPVRDLKPAIVKVYDYYETDEFAIAEYNAPCSKDLGNA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
- Cross Reference Drug Bank:
- DB00626 DB00102 DB08888
- Gene Ontology Go:
- blood microparticle
cytosol
extracellular exosome
extracellular region
platelet alpha granule lumen
calcium-dependent protein binding
enzyme binding
growth factor binding
interleukin-1 binding
interleukin-8 binding
protease binding
receptor binding
serine-type endopeptidase inhibitor activity
tumor necrosis factor binding
blood coagulation
blood coagulation, intrinsic pathway
extracellular matrix disassembly
extracellular matrix organization
negative regulation of complement activation, lectin pathway
negative regulation of endopeptidase activity
platelet activation
platelet degranulation
regulation of small GTPase mediated signal transduction
small GTPase mediated signal transduction
stem cell differentiation - Gene Ontology Biological Process:
- blood coagulation
blood coagulation, intrinsic pathway
extracellular matrix disassembly
extracellular matrix organization
negative regulation of complement activation, lectin pathway
negative regulation of endopeptidase activity
platelet activation
platelet degranulation
regulation of small GTPase mediated signal transduction
small GTPase mediated signal transduction
stem cell differentiation - Gene Ontology Molecular Function:
- calcium-dependent protein binding
enzyme binding
growth factor binding
interleukin-1 binding
interleukin-8 binding
protease binding
receptor binding
serine-type endopeptidase inhibitor activity
tumor necrosis factor binding - Gene Ontology Cellular Component:
- blood microparticle
cytosol
extracellular exosome
extracellular region
platelet alpha granule lumen - Keywords:
- 3D-structure
Bait region
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Isopeptide bond
Polymorphism
Protease inhibitor
Reference proteome
Secreted
Serine protease inhibitor
Signal
Thioester bond