Names & Taxonomy
- Uniprot ID:
- P00966
- Entry Name:
- ASSY_HUMAN
- Status:
- reviewed
- Protein Names:
- Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)
- Gene Names:
- ASS1 ASS
- Gene Names Primary:
- ASS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 412
- Sequence:
- MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDGTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYILGRESPLSLYNEELVSMNVQGDYEPTDATGFININSLRLKEYHRLQSKVTAK
- Proteomes:
- UP000005640
Function
- Function:
- Is indirectly involved in the control of blood pressure.
- Pathway:
- Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.; Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1.
- Catalytic Activity:
- ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.
- Cross Reference Drug Bank:
- DB00171 DB00125 DB00128 DB00155
- Gene Ontology Go:
- cell body fiber
cytoplasm
cytosol
endoplasmic reticulum
extracellular exosome
lysosome
mitochondrial outer membrane
nucleus
perikaryon
amino acid binding
argininosuccinate synthase activity
ATP binding
identical protein binding
poly(A) RNA binding
toxic substance binding
acute-phase response
aging
arginine biosynthetic process
argininosuccinate metabolic process
aspartate metabolic process
cellular nitrogen compound metabolic process
cellular response to amine stimulus
cellular response to amino acid stimulus
cellular response to ammonium ion
cellular response to cAMP
cellular response to dexamethasone stimulus
cellular response to glucagon stimulus
cellular response to interferon-gamma
cellular response to laminar fluid shear stress
cellular response to lipopolysaccharide
cellular response to oleic acid
cellular response to tumor necrosis factor
citrulline metabolic process
diaphragm development
kidney development
liver development
midgut development
negative regulation of leukocyte cell-cell adhesion
polyamine metabolic process
positive regulation of nitric oxide biosynthetic process
response to drug
response to estradiol
response to growth hormone
response to mycotoxin
response to nutrient
response to zinc ion
small molecule metabolic process
urea cycle - Gene Ontology Biological Process:
- acute-phase response
aging
arginine biosynthetic process
argininosuccinate metabolic process
aspartate metabolic process
cellular nitrogen compound metabolic process
cellular response to amine stimulus
cellular response to amino acid stimulus
cellular response to ammonium ion
cellular response to cAMP
cellular response to dexamethasone stimulus
cellular response to glucagon stimulus
cellular response to interferon-gamma
cellular response to laminar fluid shear stress
cellular response to lipopolysaccharide
cellular response to oleic acid
cellular response to tumor necrosis factor
citrulline metabolic process
diaphragm development
kidney development
liver development
midgut development
negative regulation of leukocyte cell-cell adhesion
polyamine metabolic process
positive regulation of nitric oxide biosynthetic process
response to drug
response to estradiol
response to growth hormone
response to mycotoxin
response to nutrient
response to zinc ion
small molecule metabolic process
urea cycle - Gene Ontology Molecular Function:
- amino acid binding
argininosuccinate synthase activity
ATP binding
identical protein binding
poly(A) RNA binding
toxic substance binding - Gene Ontology Cellular Component:
- cell body fiber
cytoplasm
cytosol
endoplasmic reticulum
extracellular exosome
lysosome
mitochondrial outer membrane
nucleus
perikaryon - Keywords:
- 3D-structure
ATP-binding
Amino-acid biosynthesis
Arginine biosynthesis
Complete proteome
Direct protein sequencing
Disease mutation
Ligase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Urea cycle - Interacts With:
- Itself; P10398