Names & Taxonomy
- Uniprot ID:
- P00749
- Entry Name:
- UROK_HUMAN
- Status:
- reviewed
- Protein Names:
- Urokinase-type plasminogen activator (U-plasminogen activator) (uPA) (EC 3.4.21.73) [Cleaved into: Urokinase-type plasminogen activator long chain A; Urokinase-type plasminogen activator short chain A; Urokinase-type plasminogen activator chain B]
- Gene Names:
- PLAU
- Gene Names Primary:
- PLAU
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 431
- Sequence:
- MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
- Catalytic Activity:
- Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by SERPINA5.
- Active Site:
- ACT_SITE 224 224 Charge relay system.; ACT_SITE 275 275 Charge relay system.; ACT_SITE 376 376 Charge relay system.
- Cross Reference Drug Bank:
- DB00594 DB00013
- Gene Ontology Go:
- cell surface
extracellular exosome
extracellular region
extracellular space
focal adhesion
plasma membrane
serine-type endopeptidase activity
angiogenesis
blood coagulation
cellular response to fluid shear stress
cellular response to glucose stimulus
cellular response to hepatocyte growth factor stimulus
cellular response to hypoxia
cellular response to lipopolysaccharide
cellular response to staurosporine
chemotaxis
embryo implantation
fibrinolysis
neuron death
positive regulation of cell proliferation
positive regulation of ovulation
positive regulation of reactive oxygen species metabolic process
positive regulation of smooth muscle cell migration
proteolysis
regulation of cell adhesion mediated by integrin
regulation of hepatocyte proliferation
regulation of receptor activity
regulation of smooth muscle cell migration
regulation of smooth muscle cell-matrix adhesion
regulation of wound healing
response to activity
response to hyperoxia
signal transduction
skeletal muscle tissue regeneration
smooth muscle cell migration
spermatogenesis - Gene Ontology Biological Process:
- angiogenesis
blood coagulation
cellular response to fluid shear stress
cellular response to glucose stimulus
cellular response to hepatocyte growth factor stimulus
cellular response to hypoxia
cellular response to lipopolysaccharide
cellular response to staurosporine
chemotaxis
embryo implantation
fibrinolysis
neuron death
positive regulation of cell proliferation
positive regulation of ovulation
positive regulation of reactive oxygen species metabolic process
positive regulation of smooth muscle cell migration
proteolysis
regulation of cell adhesion mediated by integrin
regulation of hepatocyte proliferation
regulation of receptor activity
regulation of smooth muscle cell-matrix adhesion
regulation of smooth muscle cell migration
regulation of wound healing
response to activity
response to hyperoxia
signal transduction
skeletal muscle tissue regeneration
smooth muscle cell migration
spermatogenesis - Gene Ontology Molecular Function:
- serine-type endopeptidase activity
- Gene Ontology Cellular Component:
- cell surface
extracellular exosome
extracellular region
extracellular space
focal adhesion
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Blood coagulation
Complete proteome
Direct protein sequencing
Disulfide bond
EGF-like domain
Fibrinolysis
Glycoprotein
Hemostasis
Hydrolase
Kringle
Pharmaceutical
Phosphoprotein
Plasminogen activation
Polymorphism
Protease
Reference proteome
Secreted
Serine protease
Signal
Zymogen