Names & Taxonomy
- Uniprot ID:
- P00568
- Entry Name:
- KAD1_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.3) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase)
- Gene Names:
- AK1
- Gene Names Primary:
- AK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 194
- Sequence:
- MEEKLKKTKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRSEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVAKVNTSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHLDALK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
- Catalytic Activity:
- ATP + AMP = 2 ADP.
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
outer dense fiber
plasma membrane
adenylate kinase activity
ATP binding
nucleoside diphosphate kinase activity
ADP biosynthetic process
AMP metabolic process
ATP metabolic process
cell cycle arrest
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside diphosphate phosphorylation
nucleoside triphosphate biosynthetic process
small molecule metabolic process - Gene Ontology Biological Process:
- ADP biosynthetic process
AMP metabolic process
ATP metabolic process
cell cycle arrest
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
nucleoside diphosphate phosphorylation
nucleoside triphosphate biosynthetic process
small molecule metabolic process - Gene Ontology Molecular Function:
- adenylate kinase activity
ATP binding
nucleoside diphosphate kinase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
outer dense fiber
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Hereditary hemolytic anemia
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase