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Names & Taxonomy

Uniprot ID:: P00492
Entry Name:: HPRT_HUMAN
Status:: reviewed
Protein Names:: Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8)
Gene Names:: HPRT1 HPRT
Gene Names Primary:: HPRT1
Organism:: Homo sapiens (Human)

Structure

Length:: 218
Sequence:: MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Cytoplasm.

Function

Function:: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
Pathway:: Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.
Catalytic Activity:: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.; GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.
Cofactor:: COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; ; Note=Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein.;
Kinetics:: BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=5.4 uM for IMP
Active Site:: ACT_SITE 138 138 Proton acceptor.
Cross Reference Drug Bank:: DB00993 DB01033 DB00352
Gene Ontology Go:: cytoplasm
cytosol
extracellular exosome
guanine phosphoribosyltransferase activity
hypoxanthine phosphoribosyltransferase activity
magnesium ion binding
nucleotide binding
protein homodimerization activity
adenine salvage
central nervous system neuron development
cerebral cortex neuron differentiation
cytolysis
dendrite morphogenesis
dopamine metabolic process
GMP catabolic process
GMP salvage
grooming behavior
guanine salvage
hypoxanthine metabolic process
hypoxanthine salvage
IMP metabolic process
IMP salvage
locomotory behavior
lymphocyte proliferation
nucleobase-containing small molecule metabolic process
positive regulation of dopamine metabolic process
protein homotetramerization
purine nucleobase metabolic process
purine nucleotide biosynthetic process
purine ribonucleoside salvage
purine-containing compound salvage
response to amphetamine
small molecule metabolic process
striatum development
Gene Ontology Biological Process:: adenine salvage
central nervous system neuron development
cerebral cortex neuron differentiation
cytolysis
dendrite morphogenesis
dopamine metabolic process
GMP catabolic process
GMP salvage
grooming behavior
guanine salvage
hypoxanthine metabolic process
hypoxanthine salvage
IMP metabolic process
IMP salvage
locomotory behavior
lymphocyte proliferation
nucleobase-containing small molecule metabolic process
positive regulation of dopamine metabolic process
protein homotetramerization
purine-containing compound salvage
purine nucleobase metabolic process
purine nucleotide biosynthetic process
purine ribonucleoside salvage
response to amphetamine
small molecule metabolic process
striatum development
Gene Ontology Molecular Function:: guanine phosphoribosyltransferase activity
hypoxanthine phosphoribosyltransferase activity
magnesium ion binding
nucleotide binding
protein homodimerization activity
Gene Ontology Cellular Component:: cytoplasm
cytosol
extracellular exosome
Keywords:: 3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Glycosyltransferase
Gout
Magnesium
Metal-binding
Nucleotide-binding
Phosphoprotein
Purine salvage
Reference proteome
Transferase
Interacts With:: Q9H1K1; Q9NRG1; O00560; Q96HA8

Names & Taxonomy

Structure

Subcellular location

Function

Publication