Names & Taxonomy
- Uniprot ID:
- P00414
- Entry Name:
- COX3_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome c oxidase subunit 3 (Cytochrome c oxidase polypeptide III)
- Gene Names:
- MT-CO3 COIII COXIII MTCO3
- Gene Names Primary:
- MT-CO3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 261
- Sequence:
- MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRDVTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASEYFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
- Gene Encoded:
- Mitochondrion
Function
- Function:
- Subunits I, II and III form the functional core of the enzyme complex.
- Cross Reference Drug Bank:
- DB02659
- Gene Ontology Go:
- integral component of membrane
mitochondrial inner membrane
respiratory chain complex IV
cytochrome-c oxidase activity
aerobic electron transport chain
cellular metabolic process
gene expression
respiratory chain complex IV assembly
respiratory electron transport chain
small molecule metabolic process
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- aerobic electron transport chain
cellular metabolic process
gene expression
respiratory chain complex IV assembly
respiratory electron transport chain
small molecule metabolic process
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- cytochrome-c oxidase activity
- Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial inner membrane
respiratory chain complex IV - Keywords:
- Complete proteome
Disease mutation
Leber hereditary optic neuropathy
MELAS syndrome
Membrane
Mitochondrion
Mitochondrion inner membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix - Interacts With:
- P37840