Names & Taxonomy
- Uniprot ID:
- P00403
- Entry Name:
- COX2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome c oxidase subunit 2 (Cytochrome c oxidase polypeptide II)
- Gene Names:
- MT-CO2 COII COXII MTCO2
- Gene Names Primary:
- MT-CO2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 227
- Sequence:
- MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane; Multi-pass membrane protein.
- Gene Encoded:
- Mitochondrion
Function
- Function:
- Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
- Cofactor:
- COFACTOR: Name=Cu cation; Xref=ChEBI:CHEBI:23378; ; Note=Binds a copper A center.;
- Cross Reference Drug Bank:
- DB02659
- Gene Ontology Go:
- extracellular exosome
integral component of membrane
membrane
mitochondrial inner membrane
mitochondrion
respiratory chain complex IV
copper ion binding
cytochrome-c oxidase activity
cellular metabolic process
gene expression
hydrogen ion transmembrane transport
lactation
mitochondrial electron transport, cytochrome c to oxygen
respiratory electron transport chain
response to cold
small molecule metabolic process
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- cellular metabolic process
gene expression
hydrogen ion transmembrane transport
lactation
mitochondrial electron transport, cytochrome c to oxygen
respiratory electron transport chain
response to cold
small molecule metabolic process
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- copper ion binding
cytochrome-c oxidase activity - Gene Ontology Cellular Component:
- extracellular exosome
integral component of membrane
membrane
mitochondrial inner membrane
mitochondrion
respiratory chain complex IV - Keywords:
- 3D-structure
Complete proteome
Copper
Disease mutation
Electron transport
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Polymorphism
Reference proteome
Respiratory chain
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P49281-3