Names & Taxonomy

Uniprot ID:
P00390
Entry Name:
GSHR_HUMAN
Status:
reviewed
Protein Names:
Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7)
Gene Names:
GSR GLUR GRD1
Gene Names Primary:
GSR
Organism:
Homo sapiens (Human)

Structure

Length:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform Mitochondrial: Mitochondrion.; Isoform Cytoplasmic: Cytoplasm.

Function

Function:
Maintains high levels of reduced glutathione in the cytosol.
Catalytic Activity:
2 glutathione + NADP(+) = glutathione disulfide + NADPH.
Cofactor:
COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; ; Note=Binds 1 FAD per subunit.;
Active Site:
ACT_SITE 511 511 Proton acceptor.
Cross Reference Drug Bank:
DB00262 DB03147 DB00143
Gene Ontology Go:
cytosol
external side of plasma membrane
extracellular exosome
mitochondrial matrix
electron carrier activity
flavin adenine dinucleotide binding
glutathione-disulfide reductase activity
NADP binding
cell redox homeostasis
cellular nitrogen compound metabolic process
gene expression
glutathione metabolic process
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
response to reactive oxygen species
selenium compound metabolic process
small molecule metabolic process
transcription initiation from RNA polymerase II promoter
Gene Ontology Biological Process:
cell redox homeostasis
cellular nitrogen compound metabolic process
gene expression
glutathione metabolic process
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
response to reactive oxygen species
selenium compound metabolic process
small molecule metabolic process
transcription initiation from RNA polymerase II promoter
Gene Ontology Molecular Function:
electron carrier activity
flavin adenine dinucleotide binding
glutathione-disulfide reductase activity
NADP binding
Gene Ontology Cellular Component:
cytosol
external side of plasma membrane
extracellular exosome
mitochondrial matrix
Keywords:
3D-structure
Acetylation
Alternative initiation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
FAD
Flavoprotein
Mitochondrion
NADP
Oxidoreductase
Polymorphism
Redox-active center
Reference proteome
Transit peptide

Publication

PubMed ID:
2185014 10708558 20628807 16421571 15489334 7060551 923580 15592455 21269460 24275569 25944712 7334521 3656429 8626496 9174360 9546215