Names & Taxonomy
- Uniprot ID:
- P00390
- Entry Name:
- GSHR_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7)
- Gene Names:
- GSR GLUR GRD1
- Gene Names Primary:
- GSR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 522
- Sequence:
- MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform Mitochondrial: Mitochondrion.; Isoform Cytoplasmic: Cytoplasm.
Function
- Function:
- Maintains high levels of reduced glutathione in the cytosol.
- Catalytic Activity:
- 2 glutathione + NADP(+) = glutathione disulfide + NADPH.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; ; Note=Binds 1 FAD per subunit.;
- Active Site:
- ACT_SITE 511 511 Proton acceptor.
- Cross Reference Drug Bank:
- DB00262 DB03147 DB00143
- Gene Ontology Go:
- cytosol
external side of plasma membrane
extracellular exosome
mitochondrial matrix
electron carrier activity
flavin adenine dinucleotide binding
glutathione-disulfide reductase activity
NADP binding
cell redox homeostasis
cellular nitrogen compound metabolic process
gene expression
glutathione metabolic process
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
response to reactive oxygen species
selenium compound metabolic process
small molecule metabolic process
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- cell redox homeostasis
cellular nitrogen compound metabolic process
gene expression
glutathione metabolic process
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
response to reactive oxygen species
selenium compound metabolic process
small molecule metabolic process
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- electron carrier activity
flavin adenine dinucleotide binding
glutathione-disulfide reductase activity
NADP binding - Gene Ontology Cellular Component:
- cytosol
external side of plasma membrane
extracellular exosome
mitochondrial matrix - Keywords:
- 3D-structure
Acetylation
Alternative initiation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
FAD
Flavoprotein
Mitochondrion
NADP
Oxidoreductase
Polymorphism
Redox-active center
Reference proteome
Transit peptide