Names & Taxonomy
- Uniprot ID:
- P00352
- Entry Name:
- AL1A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Retinal dehydrogenase 1 (RALDH 1) (RalDH1) (EC 1.2.1.36) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic)
- Gene Names:
- ALDH1A1 ALDC ALDH1 PUMB1
- Gene Names Primary:
- ALDH1A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 501
- Sequence:
- MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).
- Pathway:
- Cofactor metabolism; retinol metabolism.
- Catalytic Activity:
- Retinal + NAD(+) + H(2)O = retinoate + NADH.
- Active Site:
- ACT_SITE 269 269 Proton acceptor.
- Cross Reference Drug Bank:
- DB00755 DB00162
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
aldehyde dehydrogenase (NAD) activity
androgen binding
benzaldehyde dehydrogenase (NAD+) activity
GTPase activator activity
retinal dehydrogenase activity
cellular aldehyde metabolic process
ethanol oxidation
positive regulation of GTPase activity
retinol metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular aldehyde metabolic process
ethanol oxidation
positive regulation of GTPase activity
retinol metabolic process
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- aldehyde dehydrogenase (NAD) activity
androgen binding
benzaldehyde dehydrogenase (NAD+) activity
GTPase activator activity
retinal dehydrogenase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
NAD
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome