Names & Taxonomy
- Uniprot ID:
- O95977
- Entry Name:
- S1PR4_HUMAN
- Status:
- reviewed
- Protein Names:
- Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6)
- Gene Names:
- S1PR4 EDG6
- Gene Names Primary:
- S1PR4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 384
- Sequence:
- MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
lipid binding
sphingosine-1-phosphate receptor activity
activation of phospholipase C activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway
immune response
positive regulation of cytosolic calcium ion concentration - Gene Ontology Biological Process:
- activation of phospholipase C activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway
immune response
positive regulation of cytosolic calcium ion concentration - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
lipid binding
sphingosine-1-phosphate receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix