Names & Taxonomy
- Uniprot ID:
- O95932
- Entry Name:
- TGM3L_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein-glutamine gamma-glutamyltransferase 6 (EC 2.3.2.13) (Transglutaminase Y) (TGY) (TGase Y) (Transglutaminase-3-like) (TGase-3-like) (Transglutaminase-6) (TG6) (TGase-6)
- Gene Names:
- TGM6 TGM3L
- Gene Names Primary:
- TGM6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 706
- Sequence:
- MAGIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSRALDCEEILIFTMETGPRASEALHTKAVFQTSELERGEGWTAAREAQMEKTLTVSLASPPSAVIGRYLLSIRLSSHRKHSNRRLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYGQFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILQKWLKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNFNSAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATPQEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKKIGRCISTKAVGSDSRVDITDLYKYPEGSRKERQVYSKAVNRLFGVEASGRRIWIRRAGGRCLWRDDLLEPATKPSIAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVNLSGATILYTRKPVAEILHESHAVRLGPQEEKRIPITISYSKYKEDLTEDKKILLAAMCLVTKGEKLLVEKDITLEDFITIKVLGPAMVGVAVTVEVTVVNPLIERVKDCALMVEGSGLLQEQLSIDVPTLEPQERASVQFDITPSKSGPRQLQVDLVSPHFPDIKGFVIVHVATAK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
- Catalytic Activity:
- Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 274 274
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- cytoplasm
metal ion binding
protein-glutamine gamma-glutamyltransferase activity
peptide cross-linking - Gene Ontology Biological Process:
- peptide cross-linking
- Gene Ontology Molecular Function:
- metal ion binding
protein-glutamine gamma-glutamyltransferase activity - Gene Ontology Cellular Component:
- cytoplasm
- Keywords:
- Acyltransferase
Alternative splicing
Calcium
Complete proteome
Cytoplasm
Disease mutation
Metal-binding
Neurodegeneration
Polymorphism
Reference proteome
Spinocerebellar ataxia
Transferase