Names & Taxonomy
- Uniprot ID:
- O95865
- Entry Name:
- DDAH2_HUMAN
- Status:
- reviewed
- Protein Names:
- N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 (DDAH-2) (Dimethylarginine dimethylaminohydrolase 2) (EC 3.5.3.18) (DDAHII) (Dimethylargininase-2) (Protein G6a) (S-phase protein)
- Gene Names:
- DDAH2 DDAH G6A NG30
- Gene Names Primary:
- DDAH2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 285
- Sequence:
- MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEIGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGPSHLRGLCGMGGPRTVVAGSSDAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGLPGVPPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
- Catalytic Activity:
- N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline.
- Active Site:
- ACT_SITE 171 171 Proton donor.
- Cross Reference Drug Bank:
- DB00155
- Gene Ontology Go:
- centrosome
cytoplasm
cytosol
extracellular exosome
mitochondrion
amino acid binding
catalytic activity
dimethylargininase activity
arginine catabolic process
citrulline metabolic process
negative regulation of apoptotic process
nitric oxide biosynthetic process
nitric oxide mediated signal transduction
nitric oxide metabolic process
positive regulation of nitric oxide biosynthetic process
regulation of nitric-oxide synthase activity
small molecule metabolic process - Gene Ontology Biological Process:
- arginine catabolic process
citrulline metabolic process
negative regulation of apoptotic process
nitric oxide biosynthetic process
nitric oxide mediated signal transduction
nitric oxide metabolic process
positive regulation of nitric oxide biosynthetic process
regulation of nitric-oxide synthase activity
small molecule metabolic process - Gene Ontology Molecular Function:
- amino acid binding
catalytic activity
dimethylargininase activity - Gene Ontology Cellular Component:
- centrosome
cytoplasm
cytosol
extracellular exosome
mitochondrion - Keywords:
- Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Mitochondrion
Reference proteome - Interacts With:
- Q15645