Names & Taxonomy

Uniprot ID:
O95477
Entry Name:
ABCA1_HUMAN
Status:
reviewed
Protein Names:
ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein)
Gene Names:
ABCA1 ABC1 CERP
Gene Names Primary:
ABCA1
Organism:
Homo sapiens (Human)

Structure

Length:
2261
Sequence:
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDTSMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILHKVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPILRTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGSVYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVFTGITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
Cross Reference Drug Bank:
DB00171 DB01016 DB01599
Gene Ontology Go:
endocytic vesicle
external side of plasma membrane
Golgi apparatus
high-density lipoprotein particle
integral component of plasma membrane
membrane raft
perinuclear region of cytoplasm
phagocytic vesicle
plasma membrane
anion transmembrane transporter activity
apolipoprotein A-I binding
apolipoprotein A-I receptor activity
apolipoprotein binding
ATP binding
ATPase activity, coupled to transmembrane movement of substances
ATPase binding
cholesterol binding
cholesterol transporter activity
phospholipid binding
phospholipid transporter activity
receptor binding
small GTPase binding
syntaxin binding
apolipoprotein A-I-mediated signaling pathway
cellular lipid metabolic process
cellular response to cholesterol
cellular response to lipopolysaccharide
cellular response to retinoic acid
cholesterol efflux
cholesterol homeostasis
cholesterol metabolic process
endosomal transport
G-protein coupled receptor signaling pathway
high-density lipoprotein particle assembly
interleukin-1 beta secretion
intracellular cholesterol transport
lipoprotein metabolic process
lysosome organization
negative regulation of cholesterol storage
negative regulation of macrophage derived foam cell differentiation
peptide secretion
phagocytosis, engulfment
phospholipid efflux
phospholipid homeostasis
phospholipid translocation
platelet dense granule organization
positive regulation of cAMP biosynthetic process
positive regulation of cholesterol efflux
protein lipidation
regulation of Cdc42 protein signal transduction
response to drug
response to laminar fluid shear stress
response to low-density lipoprotein particle
response to nutrient
reverse cholesterol transport
small molecule metabolic process
Gene Ontology Biological Process:
apolipoprotein A-I-mediated signaling pathway
cellular lipid metabolic process
cellular response to cholesterol
cellular response to lipopolysaccharide
cellular response to retinoic acid
cholesterol efflux
cholesterol homeostasis
cholesterol metabolic process
endosomal transport
G-protein coupled receptor signaling pathway
high-density lipoprotein particle assembly
interleukin-1 beta secretion
intracellular cholesterol transport
lipoprotein metabolic process
lysosome organization
negative regulation of cholesterol storage
negative regulation of macrophage derived foam cell differentiation
peptide secretion
phagocytosis, engulfment
phospholipid efflux
phospholipid homeostasis
phospholipid translocation
platelet dense granule organization
positive regulation of cAMP biosynthetic process
positive regulation of cholesterol efflux
protein lipidation
regulation of Cdc42 protein signal transduction
response to drug
response to laminar fluid shear stress
response to low-density lipoprotein particle
response to nutrient
reverse cholesterol transport
small molecule metabolic process
Gene Ontology Molecular Function:
anion transmembrane transporter activity
apolipoprotein A-I binding
apolipoprotein A-I receptor activity
apolipoprotein binding
ATPase activity, coupled to transmembrane movement of substances
ATPase binding
ATP binding
cholesterol binding
cholesterol transporter activity
phospholipid binding
phospholipid transporter activity
receptor binding
small GTPase binding
syntaxin binding
Gene Ontology Cellular Component:
endocytic vesicle
external side of plasma membrane
Golgi apparatus
high-density lipoprotein particle
integral component of plasma membrane
membrane raft
perinuclear region of cytoplasm
phagocytic vesicle
plasma membrane
Keywords:
ATP-binding
Atherosclerosis
Cholesterol metabolism
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Lipid metabolism
Lipoprotein
Membrane
Nucleotide-binding
Palmitate
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Steroid metabolism
Sterol metabolism
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q86UK0; P02647; P60953; P55055; Q13424; Q13884; Q86Y82

Publication

PubMed ID:
10884428 11352567 15164053 10092505 10431238 12196520 11279031 12032171 17205124 12763760 18354102 19556522 19258317 19159218 24275569 10533863 10431236 10431237 11086027 10706591 10938021 11257260 11257261 11476961 11476965 11238261 12204794 12009425 11785958 12407001 12111381 12111371 14576201 12709788 12966036 12624133 15262183 15019541 15158913 15520867 15297675 15790791 16226177 15722566 16959974