Names & Taxonomy
- Uniprot ID:
- O95470
- Entry Name:
- SGPL1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sphingosine-1-phosphate lyase 1 (S1PL) (SP-lyase 1) (SPL 1) (hSPL) (EC 4.1.2.27) (Sphingosine-1-phosphate aldolase)
- Gene Names:
- SGPL1 KIAA1252
- Gene Names Primary:
- SGPL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 568
- Sequence:
- MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Single-pass type III membrane protein.
Function
- Function:
- Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.
- Pathway:
- Lipid metabolism; sphingolipid metabolism.
- Catalytic Activity:
- Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=5.2 uM for sphingosine 1-phosphate
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane
carboxy-lyase activity
pyridoxal phosphate binding
sphinganine-1-phosphate aldolase activity
androgen metabolic process
apoptotic signaling pathway
ceramide metabolic process
estrogen metabolic process
face morphogenesis
fatty acid metabolic process
fibroblast migration
hemopoiesis
kidney development
Leydig cell differentiation
luteinization
palate development
platelet-derived growth factor receptor signaling pathway
post-embryonic development
regulation of multicellular organism growth
skeletal system morphogenesis
small molecule metabolic process
spermatogenesis
sphingolipid biosynthetic process
sphingolipid catabolic process
sphingolipid metabolic process
vasculogenesis - Gene Ontology Biological Process:
- androgen metabolic process
apoptotic signaling pathway
ceramide metabolic process
estrogen metabolic process
face morphogenesis
fatty acid metabolic process
fibroblast migration
hemopoiesis
kidney development
Leydig cell differentiation
luteinization
palate development
platelet-derived growth factor receptor signaling pathway
post-embryonic development
regulation of multicellular organism growth
skeletal system morphogenesis
small molecule metabolic process
spermatogenesis
sphingolipid biosynthetic process
sphingolipid catabolic process
sphingolipid metabolic process
vasculogenesis - Gene Ontology Molecular Function:
- carboxy-lyase activity
pyridoxal phosphate binding
sphinganine-1-phosphate aldolase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane - Keywords:
- 3D-structure
Acetylation
Apoptosis
Complete proteome
Endoplasmic reticulum
Lipid metabolism
Lyase
Membrane
Nitration
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Signal-anchor
Sphingolipid metabolism
Transmembrane
Transmembrane helix - Interacts With:
- Q86WV6