Names & Taxonomy
- Uniprot ID:
- O95427
- Entry Name:
- PIGN_HUMAN
- Status:
- reviewed
- Protein Names:
- GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (MCD4 homolog) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N)
- Gene Names:
- PIGN MCD4
- Gene Names Primary:
- PIGN
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 931
- Sequence:
- MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIEQETLQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGSWLDIGTSISHYVIVMSMTIFLVFLNGLAQLLTTKKLRLCGKPKSHFM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). May act as suppressor of replication stress and chromosome missegregation.
- Pathway:
- Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
membrane
mannose-ethanolamine phosphotransferase activity
C-terminal protein lipidation
cellular protein metabolic process
GPI anchor biosynthetic process
post-translational protein modification
preassembly of GPI anchor in ER membrane - Gene Ontology Biological Process:
- cellular protein metabolic process
C-terminal protein lipidation
GPI anchor biosynthetic process
post-translational protein modification
preassembly of GPI anchor in ER membrane - Gene Ontology Molecular Function:
- mannose-ethanolamine phosphotransferase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
membrane - Keywords:
- Complete proteome
Disease mutation
Endoplasmic reticulum
Epilepsy
GPI-anchor biosynthesis
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix