Names & Taxonomy
- Uniprot ID:
- O95206
- Entry Name:
- PCDH8_HUMAN
- Status:
- reviewed
- Protein Names:
- Protocadherin-8 (Arcadlin)
- Gene Names:
- PCDH8
- Gene Names Primary:
- PCDH8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1070
- Sequence:
- MSPVRRWGSPCLFPLQLFSLCWVLSVAQSKTVRYSTFEEDAPGTVIGTLAEDLHMKVSGDTSFRLMKQFNSSLLRVREGDGQLTVGDAGLDRERLCGQAPQCVLAFDVVSFSQEQFRLVHVEVEVRDVNDHAPRFPRAQIPVEVSEGAAVGTRIPLEVPVDEDVGANGLQTVRLAEPHSPFRVELQTRADGAQCADLVLLQELDRESQAAYSLELVAQDGGRPPRSATAALSVRVLDANDHSPAFPQGAVAEVELAEDAPVGSLLLDLDAADPDEGPNGDVVFAFGARTPPEARRLFRLDPRSGRLTLAGPVDYERQDTYELDVRAQDRGPGPRAATCKVIVRIRDVNDNAPDIAITPLAAPGAPATSPFAAAAAAAALGGADASSPAGAGTPEAGATSLVPEGAARESLVALVSTSDRDSGANGQVRCALYGHEHFRLQPAYAGSYLVVTAASLDRERIAEYNLTLVAEDRGAPPLRTVRPYTVRVGDENDNAPLFTRPVYEVSVRENNPPGAYLATVAARDRDLGRNGQVTYRLLEAEVGRAGGAVSTYVSVDPATGAIYALRSFDYETLRQLDVRIQASDGGSPQLSSSALVQVRVLDQNDHAPVLVHPAPANGSLEVAVPGRTAKDTVVARVQARDADEGANGELAFELQQQEPREAFAIGRRTGEILLTGDLSQEPPGRVFRALLVISDGGRPPLTTTATVSFVVTAGGGRGPAAPASAGSPERSRPPGSRLGVSGSVLQWDTPLIVIIVLAGSCTLLLAAIIAIATTCNRRKKEVRKGGALREERPGAAGGGASAPGSPEEAARGAGPRPNMFDVLTFPGTGKAPFGSPAADAPPPAVAAAEVPGSEGGSATGESACHFEGQQRLRGAHAEPYGASPGFGKEPAPPVAVWKGHSFNTISGREAEKFSGKDSGKGDSDFNDSDSDISGDALKKDLINHMQSGLWACTAECKILGHSDRCWSPSCSGPNAHPSPHPPAQMSTFCKSTSLPRDPLRRDNYYQAQLPKTVGLQSVYEKVLHRDYDRTVTLLSPPRPGRLPDLQEIGVPLYQSPPGRYLSPKKGANENV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity).
- Gene Ontology Go:
- cell junction
dendrite
integral component of plasma membrane
plasma membrane
postsynaptic membrane
presynaptic membrane
calcium ion binding
cell-cell signaling
homophilic cell adhesion via plasma membrane adhesion molecules
morphogenesis of embryonic epithelium
somitogenesis
synaptic transmission - Gene Ontology Biological Process:
- cell-cell signaling
homophilic cell adhesion via plasma membrane adhesion molecules
morphogenesis of embryonic epithelium
somitogenesis
synaptic transmission - Gene Ontology Molecular Function:
- calcium ion binding
- Gene Ontology Cellular Component:
- cell junction
dendrite
integral component of plasma membrane
plasma membrane
postsynaptic membrane
presynaptic membrane - Keywords:
- Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cell projection
Complete proteome
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Postsynaptic cell membrane
Reference proteome
Repeat
Signal
Synapse
Transmembrane
Transmembrane helix