Names & Taxonomy

Uniprot ID:
O95190
Entry Name:
OAZ2_HUMAN
Status:
reviewed
Protein Names:
Ornithine decarboxylase antizyme 2 (AZ2) (ODC-Az 2)
Gene Names:
OAZ2
Gene Names Primary:
OAZ2
Organism:
Homo sapiens (Human)

Structure

Length:
189
Sequence:
MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
Cross Reference Drug Bank:
DB00129
Gene Ontology Go:
cytosol
nucleus
ornithine decarboxylase inhibitor activity
cellular nitrogen compound metabolic process
negative regulation of polyamine transmembrane transport
polyamine biosynthetic process
polyamine metabolic process
positive regulation of intracellular protein transport
positive regulation of protein catabolic process
regulation of cellular amino acid metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
cellular nitrogen compound metabolic process
negative regulation of polyamine transmembrane transport
polyamine biosynthetic process
polyamine metabolic process
positive regulation of intracellular protein transport
positive regulation of protein catabolic process
regulation of cellular amino acid metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
ornithine decarboxylase inhibitor activity
Gene Ontology Cellular Component:
cytosol
nucleus
Keywords:
Complete proteome
Nucleus
Phosphoprotein
Polyamine biosynthesis
Polymorphism
Reference proteome
Ribosomal frameshifting

Publication

PubMed ID:
9782076 10352227 17900240