Names & Taxonomy
- Uniprot ID:
- O95190
- Entry Name:
- OAZ2_HUMAN
- Status:
- reviewed
- Protein Names:
- Ornithine decarboxylase antizyme 2 (AZ2) (ODC-Az 2)
- Gene Names:
- OAZ2
- Gene Names Primary:
- OAZ2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 189
- Sequence:
- MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.
- Cross Reference Drug Bank:
- DB00129
- Gene Ontology Go:
- cytosol
nucleus
ornithine decarboxylase inhibitor activity
cellular nitrogen compound metabolic process
negative regulation of polyamine transmembrane transport
polyamine biosynthetic process
polyamine metabolic process
positive regulation of intracellular protein transport
positive regulation of protein catabolic process
regulation of cellular amino acid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
negative regulation of polyamine transmembrane transport
polyamine biosynthetic process
polyamine metabolic process
positive regulation of intracellular protein transport
positive regulation of protein catabolic process
regulation of cellular amino acid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- ornithine decarboxylase inhibitor activity
- Gene Ontology Cellular Component:
- cytosol
nucleus - Keywords:
- Complete proteome
Nucleus
Phosphoprotein
Polyamine biosynthesis
Polymorphism
Reference proteome
Ribosomal frameshifting