Names & Taxonomy
- Uniprot ID:
- O95069
- Entry Name:
- KCNK2_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore domain potassium channel TREK-1) (Two pore potassium channel TPKC1)
- Gene Names:
- KCNK2 TREK TREK1
- Gene Names Primary:
- KCNK2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 426
- Sequence:
- MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIAVIENIK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane
- Intramembrane:
- INTRAMEM 144 170 Pore-forming; Name=Pore-forming 1.
Function
- Function:
- Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity).
- Cross Reference Drug Bank:
- DB00204 DB04855
- Gene Ontology Go:
- apical plasma membrane
astrocyte projection
calyx of Held
cell surface
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of plasma membrane
neuronal cell body
nucleus
plasma membrane
voltage-gated potassium channel complex
outward rectifier potassium channel activity
potassium channel inhibitor activity
potassium ion leak channel activity
cardiac ventricle development
cellular response to hypoxia
cochlea development
G-protein coupled receptor signaling pathway
memory
negative regulation of cardiac muscle cell proliferation
negative regulation of DNA biosynthetic process
positive regulation of cell death
positive regulation of cellular response to hypoxia
potassium ion transmembrane transport
response to axon injury
response to mechanical stimulus
stabilization of membrane potential
synaptic transmission - Gene Ontology Biological Process:
- cardiac ventricle development
cellular response to hypoxia
cochlea development
G-protein coupled receptor signaling pathway
memory
negative regulation of cardiac muscle cell proliferation
negative regulation of DNA biosynthetic process
positive regulation of cell death
positive regulation of cellular response to hypoxia
potassium ion transmembrane transport
response to axon injury
response to mechanical stimulus
stabilization of membrane potential
synaptic transmission - Gene Ontology Molecular Function:
- outward rectifier potassium channel activity
potassium channel inhibitor activity
potassium ion leak channel activity - Gene Ontology Cellular Component:
- apical plasma membrane
astrocyte projection
calyx of Held
cell surface
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of plasma membrane
neuronal cell body
nucleus
plasma membrane
voltage-gated potassium channel complex - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport