Names & Taxonomy

Uniprot ID:
O94856
Entry Name:
NFASC_HUMAN
Status:
reviewed
Protein Names:
Neurofascin
Gene Names:
NFASC KIAA0756
Gene Names Primary:
NFASC
Organism:
Homo sapiens (Human)

Structure

Length:
1347
Sequence:
MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAPPTLPPTTVGATGAVSSTDATAIAATTEATTVPIIPTVAPTTIATTTTVATTTTTTAAATTTTESPPTTTSGTKIHESAPDEQSIWNVTVLPNSKWANITWKHNFGPGTDFVVEYIDSNHTKKTVPVKAQAQPIQLTDLYPGMTYTLRVYSRDNEGISSTVITFMTSTAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Function

Function:
Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.
Gene Ontology Go:
axon initial segment
extracellular exosome
focal adhesion
integral component of membrane
intracellular
myelin sheath
node of Ranvier
paranodal junction
paranode region of axon
plasma membrane
Schwann cell microvillus
axon guidance
clustering of voltage-gated sodium channels
heterotypic cell-cell adhesion
myelination
paranodal junction assembly
peripheral nervous system development
protein localization to juxtaparanode region of axon
protein localization to paranode region of axon
protein targeting to plasma membrane
synapse organization
transmission of nerve impulse
Gene Ontology Biological Process:
axon guidance
clustering of voltage-gated sodium channels
heterotypic cell-cell adhesion
myelination
paranodal junction assembly
peripheral nervous system development
protein localization to juxtaparanode region of axon
protein localization to paranode region of axon
protein targeting to plasma membrane
synapse organization
transmission of nerve impulse
Gene Ontology Cellular Component:
axon initial segment
extracellular exosome
focal adhesion
integral component of membrane
intracellular
myelin sheath
node of Ranvier
paranodal junction
paranode region of axon
plasma membrane
Schwann cell microvillus
Keywords:
3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
9872452 12168954 14702039 16710414 15489334 15491607 17974005 18669648 23897819 21047790