Names & Taxonomy
- Uniprot ID:
- O94856
- Entry Name:
- NFASC_HUMAN
- Status:
- reviewed
- Protein Names:
- Neurofascin
- Gene Names:
- NFASC KIAA0756
- Gene Names Primary:
- NFASC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1347
- Sequence:
- MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSMEPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVTVWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAPPTLPPTTVGATGAVSSTDATAIAATTEATTVPIIPTVAPTTIATTTTVATTTTTTAAATTTTESPPTTTSGTKIHESAPDEQSIWNVTVLPNSKWANITWKHNFGPGTDFVVEYIDSNHTKKTVPVKAQAQPIQLTDLYPGMTYTLRVYSRDNEGISSTVITFMTSTAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYTVKKDKEETEGNESSEATSPVNAIYSLA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein.
Function
- Function:
- Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.
- Gene Ontology Go:
- axon initial segment
extracellular exosome
focal adhesion
integral component of membrane
intracellular
myelin sheath
node of Ranvier
paranodal junction
paranode region of axon
plasma membrane
Schwann cell microvillus
axon guidance
clustering of voltage-gated sodium channels
heterotypic cell-cell adhesion
myelination
paranodal junction assembly
peripheral nervous system development
protein localization to juxtaparanode region of axon
protein localization to paranode region of axon
protein targeting to plasma membrane
synapse organization
transmission of nerve impulse - Gene Ontology Biological Process:
- axon guidance
clustering of voltage-gated sodium channels
heterotypic cell-cell adhesion
myelination
paranodal junction assembly
peripheral nervous system development
protein localization to juxtaparanode region of axon
protein localization to paranode region of axon
protein targeting to plasma membrane
synapse organization
transmission of nerve impulse - Gene Ontology Cellular Component:
- axon initial segment
extracellular exosome
focal adhesion
integral component of membrane
intracellular
myelin sheath
node of Ranvier
paranodal junction
paranode region of axon
plasma membrane
Schwann cell microvillus - Keywords:
- 3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix