Names & Taxonomy

Uniprot ID:
O75908
Entry Name:
SOAT2_HUMAN
Status:
reviewed
Protein Names:
Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2)
Gene Names:
SOAT2 ACACT2 ACAT2
Gene Names Primary:
SOAT2
Organism:
Homo sapiens (Human)

Structure

Length:
522
Sequence:
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein.

Function

Function:
Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
Catalytic Activity:
Acyl-CoA + cholesterol = CoA + cholesterol ester.
Active Site:
ACT_SITE 434 434
Cross Reference Drug Bank:
DB01094
Gene Ontology Go:
brush border
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
cholesterol binding
cholesterol O-acyltransferase activity
fatty-acyl-CoA binding
transferase activity, transferring acyl groups
cholesterol efflux
cholesterol esterification
cholesterol homeostasis
cholesterol metabolic process
intestinal cholesterol absorption
macrophage derived foam cell differentiation
very-low-density lipoprotein particle assembly
Gene Ontology Biological Process:
cholesterol efflux
cholesterol esterification
cholesterol homeostasis
cholesterol metabolic process
intestinal cholesterol absorption
macrophage derived foam cell differentiation
very-low-density lipoprotein particle assembly
Gene Ontology Molecular Function:
cholesterol binding
cholesterol O-acyltransferase activity
fatty-acyl-CoA binding
transferase activity, transferring acyl groups
Gene Ontology Cellular Component:
brush border
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
Keywords:
Acyltransferase
Alternative splicing
Cholesterol metabolism
Complete proteome
Endoplasmic reticulum
Lipid metabolism
Membrane
Polymorphism
Reference proteome
Steroid metabolism
Sterol metabolism
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
9756920 10846185 11325614 11401500 16541075 15489334 16331323