Names & Taxonomy
- Uniprot ID:
- O75908
- Entry Name:
- SOAT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2)
- Gene Names:
- SOAT2 ACACT2 ACAT2
- Gene Names Primary:
- SOAT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 522
- Sequence:
- MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Multi-pass membrane protein.
Function
- Function:
- Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
- Catalytic Activity:
- Acyl-CoA + cholesterol = CoA + cholesterol ester.
- Active Site:
- ACT_SITE 434 434
- Cross Reference Drug Bank:
- DB01094
- Gene Ontology Go:
- brush border
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
cholesterol binding
cholesterol O-acyltransferase activity
fatty-acyl-CoA binding
transferase activity, transferring acyl groups
cholesterol efflux
cholesterol esterification
cholesterol homeostasis
cholesterol metabolic process
intestinal cholesterol absorption
macrophage derived foam cell differentiation
very-low-density lipoprotein particle assembly - Gene Ontology Biological Process:
- cholesterol efflux
cholesterol esterification
cholesterol homeostasis
cholesterol metabolic process
intestinal cholesterol absorption
macrophage derived foam cell differentiation
very-low-density lipoprotein particle assembly - Gene Ontology Molecular Function:
- cholesterol binding
cholesterol O-acyltransferase activity
fatty-acyl-CoA binding
transferase activity, transferring acyl groups - Gene Ontology Cellular Component:
- brush border
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Acyltransferase
Alternative splicing
Cholesterol metabolism
Complete proteome
Endoplasmic reticulum
Lipid metabolism
Membrane
Polymorphism
Reference proteome
Steroid metabolism
Sterol metabolism
Transferase
Transmembrane
Transmembrane helix