Names & Taxonomy
- Uniprot ID:
- O75879
- Entry Name:
- GATB_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112 homolog)
- Gene Names:
- GATB PET112 PET112L HSPC199
- Gene Names Orf:
- HSPC199
- Gene Names Primary:
- GATB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 557
- Sequence:
- MAAPMLRWGCRGRRWAFARVDGGSCHRRGAPTGSTSNQIRGESSVAQQPLHTAQKTRKGEHKWAAVVGLEIHAQISSNSKLFSGSQVRFSAPPNSLVSFFDASLPGTLPVLNRRCVEAAVMTGLALNCHINKKSLFDRKHYFYADLPAGYQITQQRLPIAVNGSLIYGVCAGKKQSQVIPKTVRIKQIQLEQDSGKSLHDNLRSQTLIDLNRAGVGLLEVVLEPDMSCGEEAATAVRELQLILQALGTSQANMAEGQLRVDANISVHHPGEPLGVRTEVKNLNSIRFLAKAIDYEIQRQINELENGGEILNETRSFHHKLGCTMSMRDKEGKQDYRFMPEPNLPPLVLYDATSLPAGADPQQVINIDQIRETLPELPSVTREKLVQQYGMLLEHSFTLLNEVGLLEFFQNVIKETRAEPKKVTSWVLNTFLGYLKQQNLAVSESPVTPSALAELLDLLDSRTISSSAAKQVFEELWKREGKTPGQIVSEKQLELMQDQGALEQLCHSVMEAHPQVVMDVKNRNPRAINKLIGLVRKATQSRADPVMIKEILEKKLSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
- Catalytic Activity:
- ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- glutamyl-tRNA(Gln) amidotransferase complex
mitochondrion
ATP binding
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
translation factor activity, RNA binding
glutaminyl-tRNAGln biosynthesis via transamidation
mitochondrial translation
translation - Gene Ontology Biological Process:
- glutaminyl-tRNAGln biosynthesis via transamidation
mitochondrial translation
translation - Gene Ontology Molecular Function:
- ATP binding
glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
translation factor activity, RNA binding - Gene Ontology Cellular Component:
- glutamyl-tRNA(Gln) amidotransferase complex
mitochondrion - Keywords:
- ATP-binding
Complete proteome
Direct protein sequencing
Ligase
Mitochondrion
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide