Names & Taxonomy
- Uniprot ID:
- O75874
- Entry Name:
- IDHC_HUMAN
- Status:
- reviewed
- Protein Names:
- Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)
- Gene Names:
- IDH1 PICD
- Gene Names Primary:
- IDH1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 414
- Sequence:
- MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Catalytic Activity:
- Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=49 uM for NADP
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
mitochondrion
peroxisomal matrix
peroxisome
isocitrate dehydrogenase (NADP+) activity
magnesium ion binding
NAD binding
NADP binding
protein homodimerization activity
receptor binding
2-oxoglutarate metabolic process
cellular lipid metabolic process
female gonad development
glutathione metabolic process
glyoxylate cycle
isocitrate metabolic process
NADPH regeneration
regulation of phospholipid biosynthetic process
regulation of phospholipid catabolic process
response to oxidative stress
response to steroid hormone
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Biological Process:
- 2-oxoglutarate metabolic process
cellular lipid metabolic process
female gonad development
glutathione metabolic process
glyoxylate cycle
isocitrate metabolic process
NADPH regeneration
regulation of phospholipid biosynthetic process
regulation of phospholipid catabolic process
response to oxidative stress
response to steroid hormone
small molecule metabolic process
tricarboxylic acid cycle - Gene Ontology Molecular Function:
- isocitrate dehydrogenase (NADP+) activity
magnesium ion binding
NAD binding
NADP binding
protein homodimerization activity
receptor binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
mitochondrion
peroxisomal matrix
peroxisome - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Glyoxylate bypass
Magnesium
Manganese
Metal-binding
NADP
Oxidoreductase
Peroxisome
Phosphoprotein
Polymorphism
Reference proteome
Tricarboxylic acid cycle