Names & Taxonomy

Uniprot ID:
O75874
Entry Name:
IDHC_HUMAN
Status:
reviewed
Protein Names:
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase)
Gene Names:
IDH1 PICD
Gene Names Primary:
IDH1
Organism:
Homo sapiens (Human)

Structure

Length:
414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Catalytic Activity:
Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=49 uM for NADP
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
mitochondrion
peroxisomal matrix
peroxisome
isocitrate dehydrogenase (NADP+) activity
magnesium ion binding
NAD binding
NADP binding
protein homodimerization activity
receptor binding
2-oxoglutarate metabolic process
cellular lipid metabolic process
female gonad development
glutathione metabolic process
glyoxylate cycle
isocitrate metabolic process
NADPH regeneration
regulation of phospholipid biosynthetic process
regulation of phospholipid catabolic process
response to oxidative stress
response to steroid hormone
small molecule metabolic process
tricarboxylic acid cycle
Gene Ontology Biological Process:
2-oxoglutarate metabolic process
cellular lipid metabolic process
female gonad development
glutathione metabolic process
glyoxylate cycle
isocitrate metabolic process
NADPH regeneration
regulation of phospholipid biosynthetic process
regulation of phospholipid catabolic process
response to oxidative stress
response to steroid hormone
small molecule metabolic process
tricarboxylic acid cycle
Gene Ontology Molecular Function:
isocitrate dehydrogenase (NADP+) activity
magnesium ion binding
NAD binding
NADP binding
protein homodimerization activity
receptor binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
mitochondrion
peroxisomal matrix
peroxisome
Keywords:
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Glyoxylate bypass
Magnesium
Manganese
Metal-binding
NADP
Oxidoreductase
Peroxisome
Phosphoprotein
Polymorphism
Reference proteome
Tricarboxylic acid cycle

Publication

PubMed ID:
9866202 10521434 11230166 17974005 15815621 15489334 19608861 21269460 22814378 24275569 25944712 15173171 19935646 16959974 18772396 19117336