Names & Taxonomy
- Uniprot ID:
- O75751
- Entry Name:
- S22A3_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3)
- Gene Names:
- SLC22A3 EMTH OCT3
- Gene Names Primary:
- SLC22A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 556
- Sequence:
- MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHSCKCGRNKKTPVSRSHL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
- Cross Reference Drug Bank:
- DB00718 DB00182 DB00122 DB00501 DB00575 DB01394 DB01151 DB00988 DB00783 DB00536 DB00667 DB00458 DB00762 DB00709 DB01042 DB00331 DB01577 DB00184 DB00368 DB00526 DB00925 DB00457 DB01035 DB00396 DB00624 DB00541
- Gene Ontology Go:
- integral component of plasma membrane
membrane
plasma membrane
dopamine transmembrane transporter activity
organic cation transmembrane transporter activity
quaternary ammonium group transmembrane transporter activity
toxin transporter activity
dopamine transport
drug transmembrane transport
histamine uptake
mitophagy in response to mitochondrial depolarization
organic cation transport
quaternary ammonium group transport
regulation of appetite
small molecule metabolic process
transmembrane transport - Gene Ontology Biological Process:
- dopamine transport
drug transmembrane transport
histamine uptake
mitophagy in response to mitochondrial depolarization
organic cation transport
quaternary ammonium group transport
regulation of appetite
small molecule metabolic process
transmembrane transport - Gene Ontology Molecular Function:
- dopamine transmembrane transporter activity
organic cation transmembrane transporter activity
quaternary ammonium group transmembrane transporter activity
toxin transporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Complete proteome
Glycoprotein
Ion transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P00519