Names & Taxonomy
- Uniprot ID:
- O75746
- Entry Name:
- CMC1_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcium-binding mitochondrial carrier protein Aralar1 (Mitochondrial aspartate glutamate carrier 1) (Solute carrier family 25 member 12)
- Gene Names:
- SLC25A12 ARALAR1
- Gene Names Primary:
- SLC25A12
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 678
- Sequence:
- MAVKVQTTKRGDPHELRNIFLQYASTEVDGERYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFGHNRKKHLNYTEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDIMVTIRSHMLTPFVEENLVSAAGGSISHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDVEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPAGSEPTPKSRIADLPPANPDHIGGYRLATATFAGIENKFGLYLPKFKSPSVAVVQPKAAVAATQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
Function
- Function:
- Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.
- Cross Reference Drug Bank:
- DB00128
- Gene Ontology Go:
- integral component of membrane
mitochondrial inner membrane
mitochondrion
myelin sheath
calcium ion binding
L-aspartate transmembrane transporter activity
L-glutamate transmembrane transporter activity
structural constituent of ribosome
aspartate transport
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
L-aspartate transmembrane transport
L-glutamate transmembrane transport
L-glutamate transport
malate-aspartate shuttle
response to calcium ion
small molecule metabolic process
translation - Gene Ontology Biological Process:
- aspartate transport
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
L-aspartate transmembrane transport
L-glutamate transmembrane transport
L-glutamate transport
malate-aspartate shuttle
response to calcium ion
small molecule metabolic process
translation - Gene Ontology Molecular Function:
- calcium ion binding
L-aspartate transmembrane transporter activity
L-glutamate transmembrane transporter activity
structural constituent of ribosome - Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial inner membrane
mitochondrion
myelin sheath - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Calcium
Complete proteome
Disease mutation
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport