Names & Taxonomy
- Uniprot ID:
- O75715
- Entry Name:
- GPX5_HUMAN
- Status:
- reviewed
- Protein Names:
- Epididymal secretory glutathione peroxidase (EC 1.11.1.9) (Epididymis-specific glutathione peroxidase-like protein) (EGLP) (Glutathione peroxidase 5) (GPx-5) (GSHPx-5)
- Gene Names:
- GPX5
- Gene Names Primary:
- GPX5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 221
- Sequence:
- MTTQLRVVHLLPLLLACFVQTSPKQEKMKMDCHKDEKGTIYDYEAIALNKNEYVSFKQYVGKHILFVNVATYCGLTAQYPELNALQEELKPYGLVVLGFPCNQFGKQEPGDNKEILPGLKYVRPGGGFVPSFQLFEKGDVNGEKEQKVFSFLKHSCPHPSEILGTFKSISWDPVKVHDIRWNFEKFLVGPDGIPVMRWSHRATVSSVKTDILAYLKQFKTK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
- Catalytic Activity:
- 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
- Active Site:
- ACT_SITE 73 73
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- extracellular space
sperm plasma membrane
glutathione peroxidase activity
cellular response to oxidative stress
lipid metabolic process - Gene Ontology Biological Process:
- cellular response to oxidative stress
lipid metabolic process - Gene Ontology Molecular Function:
- glutathione peroxidase activity
- Gene Ontology Cellular Component:
- extracellular space
sperm plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Secreted
Signal