Names & Taxonomy

Uniprot ID:
O75390
Entry Name:
CISY_HUMAN
Status:
reviewed
Protein Names:
Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase)
Gene Names:
CS
Gene Names Primary:
CS
Organism:
Homo sapiens (Human)

Structure

Length:
466
Sequence:
MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLFWLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFARAYAQGISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix.

Function

Pathway:
Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.
Catalytic Activity:
Acetyl-CoA + H(2)O + oxaloacetate = citrate + CoA.
Active Site:
ACT_SITE 301 301
Gene Ontology Go:
extracellular exosome
mitochondrial matrix
mitochondrion
nucleus
citrate (Si)-synthase activity
poly(A) RNA binding
carbohydrate metabolic process
cellular metabolic process
small molecule metabolic process
tricarboxylic acid cycle
Gene Ontology Biological Process:
carbohydrate metabolic process
cellular metabolic process
small molecule metabolic process
tricarboxylic acid cycle
Gene Ontology Molecular Function:
citrate (Si)-synthase activity
poly(A) RNA binding
Gene Ontology Cellular Component:
extracellular exosome
mitochondrial matrix
mitochondrion
nucleus
Keywords:
Acetylation
Complete proteome
Direct protein sequencing
Methylation
Mitochondrion
Reference proteome
Transferase
Transit peptide
Tricarboxylic acid cycle

Publication

PubMed ID:
9809442 12549038 14702039 17974005 15489334 15242332 19608861 21269460 24275569 25944712