Names & Taxonomy
- Uniprot ID:
- O75311
- Entry Name:
- GLRA3_HUMAN
- Status:
- reviewed
- Protein Names:
- Glycine receptor subunit alpha-3
- Gene Names:
- GLRA3
- Gene Names Primary:
- GLRA3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 464
- Sequence:
- MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane
Function
- Function:
- Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity).
- Cross Reference Drug Bank:
- DB00145 DB00602 DB00431
- Gene Ontology Go:
- cell junction
dendrite
glycine-gated chloride channel complex
integral component of plasma membrane
perikaryon
plasma membrane
postsynaptic membrane
extracellular-glycine-gated chloride channel activity
glycine binding
glycine-gated chloride ion channel activity
metal ion binding
chloride transmembrane transport
ion transmembrane transport
neuropeptide signaling pathway
protein homooligomerization
response to amino acid
synaptic transmission, glycinergic
transmembrane transport - Gene Ontology Biological Process:
- chloride transmembrane transport
ion transmembrane transport
neuropeptide signaling pathway
protein homooligomerization
response to amino acid
synaptic transmission, glycinergic
transmembrane transport - Gene Ontology Molecular Function:
- extracellular-glycine-gated chloride channel activity
glycine binding
glycine-gated chloride ion channel activity
metal ion binding - Gene Ontology Cellular Component:
- cell junction
dendrite
glycine-gated chloride channel complex
integral component of plasma membrane
perikaryon
plasma membrane
postsynaptic membrane - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Cell membrane
Cell projection
Chloride
Chloride channel
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Metal-binding
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport