Names & Taxonomy
- Uniprot ID:
- O75306
- Entry Name:
- NDUS2_HUMAN
- Status:
- reviewed
- Protein Names:
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 1.6.5.3) (EC 1.6.99.3) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit)
- Gene Names:
- NDUFS2
- Gene Names Primary:
- NDUFS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 463
- Sequence:
- MAALRALCGFRGVAAQVLRPGAGVRLPIQPSRGVRQWQPDVEWAQQFGGAVMYPSKETAHWKPPPWNDVDPPKDTIVKNITLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIRPPPRAQWIRVLFGEITRLLNHIMAVTTHALDLGAMTPFFWLFEEREKMFEFYERVSGARMHAAYIRPGGVHQDLPLGLMDDIYQFSKNFSLRLDELEELLTNNRIWRNRTIDIGVVTAEEALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPVGSRGDCYDRYLCRVEEMRQSLRIIAQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Function
- Function:
- Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
- Catalytic Activity:
- NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).; NADH + acceptor = NAD(+) + reduced acceptor.
- Cofactor:
- COFACTOR: Name= cluster; Xref=ChEBI:CHEBI:49883; ; Note=Binds 1 cluster.;
- Cross Reference Drug Bank:
- DB00997
- Gene Ontology Go:
- mitochondrial matrix
mitochondrial respiratory chain complex I
mitochondrion
nucleoplasm
4 iron, 4 sulfur cluster binding
electron carrier activity
metal ion binding
NAD binding
NADH dehydrogenase (ubiquinone) activity
quinone binding
ubiquitin protein ligase binding
cellular metabolic process
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I assembly
respiratory electron transport chain
response to oxidative stress
small molecule metabolic process - Gene Ontology Biological Process:
- cellular metabolic process
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I assembly
respiratory electron transport chain
response to oxidative stress
small molecule metabolic process - Gene Ontology Molecular Function:
- 4 iron, 4 sulfur cluster binding
electron carrier activity
metal ion binding
NAD binding
NADH dehydrogenase (ubiquinone) activity
quinone binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrial respiratory chain complex I
mitochondrion
nucleoplasm - Keywords:
- 4Fe-4S
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Electron transport
Iron
Iron-sulfur
Membrane
Metal-binding
Methylation
Mitochondrion
Mitochondrion inner membrane
NAD
Oxidoreductase
Polymorphism
Reference proteome
Respiratory chain
Transit peptide
Transport
Ubiquinone - Interacts With:
- O75489