Names & Taxonomy

Uniprot ID:
O75185
Entry Name:
AT2C2_HUMAN
Status:
reviewed
Protein Names:
Calcium-transporting ATPase type 2C member 2 (ATPase 2C2) (EC 3.6.3.8) (Secretory pathway Ca(2+)-ATPase 2)
Gene Names:
ATP2C2 KIAA0703 SPCA2
Gene Names Primary:
ATP2C2
Organism:
Homo sapiens (Human)

Structure

Length:
946
Sequence:
MVEGRVSEFLKKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELTKMVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDIKNSYIRKKEIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTLFIFWKEMPEDRASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQMHPEDV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Catalytic Activity:
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
Active Site:
ACT_SITE 379 379 4-aspartylphosphate intermediate.
Gene Ontology Go:
Golgi membrane
integral component of plasma membrane
ATP binding
calcium-transporting ATPase activity
manganese-transporting ATPase activity
metal ion binding
cellular calcium ion homeostasis
ion transmembrane transport
manganese ion transmembrane transport
transmembrane transport
Gene Ontology Biological Process:
cellular calcium ion homeostasis
ion transmembrane transport
manganese ion transmembrane transport
transmembrane transport
Gene Ontology Molecular Function:
ATP binding
calcium-transporting ATPase activity
manganese-transporting ATPase activity
metal ion binding
Gene Ontology Cellular Component:
Golgi membrane
integral component of plasma membrane
Keywords:
ATP-binding
Alternative splicing
Calcium
Calcium transport
Complete proteome
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q96D31

Publication

PubMed ID:
15831496 9734811 14702039 17974005 15616553 18669648