Names & Taxonomy
- Uniprot ID:
- O75173
- Entry Name:
- ATS4_HUMAN
- Status:
- reviewed
- Protein Names:
- A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1)
- Gene Names:
- ADAMTS4 KIAA0688 UNQ769/PRO1563
- Gene Names Orf:
- UNQ769/PRO1563
- Gene Names Primary:
- ADAMTS4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 837
- Sequence:
- MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
- Catalytic Activity:
- Glutamyl endopeptidase; bonds cleaved include 370-Thr-Glu-Gly-Glu-|-Ala-Arg-Gly-Ser-377 in the interglobular domain of mammalian aggrecan.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 362 362
- Cross Reference Drug Bank:
- DB06822
- Gene Ontology Go:
- extracellular matrix
extracellular region
extracellular space
proteinaceous extracellular matrix
metalloendopeptidase activity
metallopeptidase activity
peptidase activity
protease binding
zinc ion binding
extracellular matrix disassembly
extracellular matrix organization
proteolysis
skeletal system development - Gene Ontology Biological Process:
- extracellular matrix disassembly
extracellular matrix organization
proteolysis
skeletal system development - Gene Ontology Molecular Function:
- metalloendopeptidase activity
metallopeptidase activity
peptidase activity
protease binding
zinc ion binding - Gene Ontology Cellular Component:
- extracellular matrix
extracellular region
extracellular space
proteinaceous extracellular matrix - Keywords:
- 3D-structure
Alternative splicing
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Secreted
Signal
Zinc
Zymogen