Names & Taxonomy
- Uniprot ID:
- O75094
- Entry Name:
- SLIT3_HUMAN
- Status:
- reviewed
- Protein Names:
- Slit homolog 3 protein (Slit-3) (Multiple epidermal growth factor-like domains protein 5) (Multiple EGF-like domains protein 5)
- Gene Names:
- SLIT3 KIAA0814 MEGF5 SLIL2 UNQ691/PRO1336
- Gene Names Orf:
- UNQ691/PRO1336
- Gene Names Primary:
- SLIT3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1523
- Sequence:
- MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIVKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLACS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
- Gene Ontology Go:
- extracellular space
mitochondrion
proteinaceous extracellular matrix
calcium ion binding
heparin binding
Roundabout binding
apoptotic process involved in luteolysis
axon extension involved in axon guidance
axon guidance
cellular response to hormone stimulus
negative chemotaxis
negative regulation of cell growth
negative regulation of cell proliferation
negative regulation of chemokine-mediated signaling pathway
negative regulation of gene expression
organ morphogenesis
regulation of axonogenesis
response to cortisol
Roundabout signaling pathway - Gene Ontology Biological Process:
- apoptotic process involved in luteolysis
axon extension involved in axon guidance
axon guidance
cellular response to hormone stimulus
negative chemotaxis
negative regulation of cell growth
negative regulation of cell proliferation
negative regulation of chemokine-mediated signaling pathway
negative regulation of gene expression
organ morphogenesis
regulation of axonogenesis
response to cortisol
Roundabout signaling pathway - Gene Ontology Molecular Function:
- calcium ion binding
heparin binding
Roundabout binding - Gene Ontology Cellular Component:
- extracellular space
mitochondrion
proteinaceous extracellular matrix - Keywords:
- Alternative splicing
Complete proteome
Developmental protein
Differentiation
Disulfide bond
EGF-like domain
Glycoprotein
Leucine-rich repeat
Neurogenesis
Polymorphism
Reference proteome
Repeat
Secreted
Signal