Names & Taxonomy
- Uniprot ID:
- O60896
- Entry Name:
- RAMP3_HUMAN
- Status:
- reviewed
- Protein Names:
- Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3)
- Gene Names:
- RAMP3
- Gene Names Primary:
- RAMP3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 148
- Sequence:
- METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.
- Cross Reference Drug Bank:
- DB01278
- Gene Ontology Go:
- cell surface
integral component of plasma membrane
intracellular
lysosome
plasma membrane
receptor complex
coreceptor activity
protein transporter activity
receptor activity
calcium ion transport
cellular response to estradiol stimulus
G-protein coupled receptor signaling pathway involved in heart process
intracellular protein transport
negative regulation of transcription, DNA-templated
positive regulation of establishment of protein localization to plasma membrane
positive regulation of receptor recycling
protein localization to plasma membrane
protein transport
receptor internalization
regulation of G-protein coupled receptor protein signaling pathway - Gene Ontology Biological Process:
- calcium ion transport
cellular response to estradiol stimulus
G-protein coupled receptor signaling pathway involved in heart process
intracellular protein transport
negative regulation of transcription, DNA-templated
positive regulation of establishment of protein localization to plasma membrane
positive regulation of receptor recycling
protein localization to plasma membrane
protein transport
receptor internalization
regulation of G-protein coupled receptor protein signaling pathway - Gene Ontology Molecular Function:
- coreceptor activity
protein transporter activity
receptor activity - Gene Ontology Cellular Component:
- cell surface
integral component of plasma membrane
intracellular
lysosome
plasma membrane
receptor complex - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P26371; Q7Z3S9