Names & Taxonomy
- Uniprot ID:
- O60894
- Entry Name:
- RAMP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1)
- Gene Names:
- RAMP1
- Gene Names Primary:
- RAMP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 148
- Sequence:
- MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.
- Cross Reference Drug Bank:
- DB01278
- Gene Ontology Go:
- cell surface
extracellular space
integral component of plasma membrane
intracellular
plasma membrane
receptor complex
calcitonin receptor activity
calcitonin receptor binding
coreceptor activity
protein transporter activity
receptor activity
angiogenesis
calcium ion transport
intracellular protein transport
positive regulation of cAMP biosynthetic process
positive regulation of protein glycosylation
protein localization to plasma membrane
protein transport
receptor internalization
regulation of G-protein coupled receptor protein signaling pathway - Gene Ontology Biological Process:
- angiogenesis
calcium ion transport
intracellular protein transport
positive regulation of cAMP biosynthetic process
positive regulation of protein glycosylation
protein localization to plasma membrane
protein transport
receptor internalization
regulation of G-protein coupled receptor protein signaling pathway - Gene Ontology Molecular Function:
- calcitonin receptor activity
calcitonin receptor binding
coreceptor activity
protein transporter activity
receptor activity - Gene Ontology Cellular Component:
- cell surface
extracellular space
integral component of plasma membrane
intracellular
plasma membrane
receptor complex - Keywords:
- 3D-structure
Complete proteome
Disulfide bond
Membrane
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
Transport