Names & Taxonomy
- Uniprot ID:
- O60825
- Entry Name:
- F262_HUMAN
- Status:
- reviewed
- Protein Names:
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
- Gene Names:
- PFKFB2
- Gene Names Primary:
- PFKFB2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 505
- Sequence:
- MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEENGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVYYLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPRNYSVGSRPLKPLSPLRAQDMQEGAD
- Proteomes:
- UP000005640
Function
- Function:
- Synthesis and degradation of fructose 2,6-bisphosphate.
- Catalytic Activity:
- Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.; ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Phosphorylation results in the activation of the kinase activity.
- Active Site:
- ACT_SITE 128 128
- Gene Ontology Go:
- cytosol
6-phosphofructo-2-kinase activity
ATP binding
fructose-2,6-bisphosphate 2-phosphatase activity
protein kinase binding
canonical glycolysis
carbohydrate metabolic process
carbohydrate phosphorylation
fructose 2,6-bisphosphate metabolic process
fructose metabolic process
glucose metabolic process
glycolytic process
lactate metabolic process
positive regulation of glucokinase activity
positive regulation of insulin secretion
response to glucose
small molecule metabolic process - Gene Ontology Biological Process:
- canonical glycolysis
carbohydrate metabolic process
carbohydrate phosphorylation
fructose 2,6-bisphosphate metabolic process
fructose metabolic process
glucose metabolic process
glycolytic process
lactate metabolic process
positive regulation of glucokinase activity
positive regulation of insulin secretion
response to glucose
small molecule metabolic process - Gene Ontology Molecular Function:
- 6-phosphofructo-2-kinase activity
ATP binding
fructose-2,6-bisphosphate 2-phosphatase activity
protein kinase binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- ATP-binding
Acetylation
Alternative splicing
Complete proteome
Hydrolase
Kinase
Multifunctional enzyme
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase