Names & Taxonomy
- Uniprot ID:
- O60760
- Entry Name:
- HPGDS_HUMAN
- Status:
- reviewed
- Protein Names:
- Hematopoietic prostaglandin D synthase (H-PGDS) (EC 5.3.99.2) (GST class-sigma) (Glutathione S-transferase) (EC 2.5.1.18) (Glutathione-dependent PGD synthase) (Glutathione-requiring prostaglandin D synthase) (Prostaglandin-H2 D-isomerase)
- Gene Names:
- HPGDS GSTS PGDS PTGDS2
- Gene Names Primary:
- HPGDS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 199
- Sequence:
- MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.
- Catalytic Activity:
- (5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.
- Cofactor:
- COFACTOR: Name=glutathione; Xref=ChEBI:CHEBI:57925;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=8 mM for glutathione for the glutathione-conjugating activity
- Enzyme Regulation:
- ENZYME REGULATION: Prostaglandin PGD2 synthesis is stimulated by calcium and magnesium ions. One calcium or magnesium ion is bound between the subunits of the homodimer. The interactions with the protein are for the most part mediated via water molecules. Magnesium increases the affinity for glutathione, while calcium has no effect on the affinity for glutathione.
- Cross Reference Drug Bank:
- DB00143 DB07615
- Gene Ontology Go:
- cytoplasm
cytosol
calcium ion binding
glutathione transferase activity
magnesium ion binding
prostaglandin-D synthase activity
protein homodimerization activity
arachidonic acid metabolic process
cyclooxygenase pathway
glutathione derivative biosynthetic process
locomotory behavior
negative regulation of male germ cell proliferation
prostaglandin metabolic process
signal transduction
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- arachidonic acid metabolic process
cyclooxygenase pathway
glutathione derivative biosynthetic process
locomotory behavior
negative regulation of male germ cell proliferation
prostaglandin metabolic process
signal transduction
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- calcium ion binding
glutathione transferase activity
magnesium ion binding
prostaglandin-D synthase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol - Keywords:
- 3D-structure
Calcium
Complete proteome
Cytoplasm
Fatty acid biosynthesis
Fatty acid metabolism
Isomerase
Lipid biosynthesis
Lipid metabolism
Magnesium
Metal-binding
Prostaglandin biosynthesis
Prostaglandin metabolism
Reference proteome
Transferase - Interacts With:
- Q96GS6; Q96B67; P08582-2