Names & Taxonomy
- Uniprot ID:
- O60658
- Entry Name:
- PDE8A_HUMAN
- Status:
- reviewed
- Protein Names:
- High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53)
- Gene Names:
- PDE8A
- Gene Names Primary:
- PDE8A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 829
- Sequence:
- MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE
- Proteomes:
- UP000005640
Function
- Function:
- Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
- Pathway:
- Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
- Catalytic Activity:
- Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by dipyridimole. Insensitive to selective PDE inhibitors including rolipram and zaprinast as well as to the non-selective inhibitor, IBMX. Unaffected by cGMP.
- Active Site:
- ACT_SITE 556 556 Proton donor.
- Cross Reference Drug Bank:
- DB00201 DB00920
- Gene Ontology Go:
- cytosol
extracellular exosome
3',5'-cyclic-AMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
metal ion binding
cAMP catabolic process
cyclic nucleotide metabolic process
regulation of transcription, DNA-templated
signal transduction - Gene Ontology Biological Process:
- cAMP catabolic process
cyclic nucleotide metabolic process
regulation of transcription, DNA-templated
signal transduction - Gene Ontology Molecular Function:
- 3',5'-cyclic-AMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Hydrolase
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
cAMP