Names & Taxonomy

Uniprot ID:
O60658
Entry Name:
PDE8A_HUMAN
Status:
reviewed
Protein Names:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53)
Gene Names:
PDE8A
Gene Names Primary:
PDE8A
Organism:
Homo sapiens (Human)

Structure

Length:
829
Sequence:
MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE
Proteomes:
UP000005640

Function

Function:
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
Pathway:
Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Catalytic Activity:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
Cofactor:
COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
Enzyme Regulation:
ENZYME REGULATION: Inhibited by dipyridimole. Insensitive to selective PDE inhibitors including rolipram and zaprinast as well as to the non-selective inhibitor, IBMX. Unaffected by cGMP.
Active Site:
ACT_SITE 556 556 Proton donor.
Cross Reference Drug Bank:
DB00201 DB00920
Gene Ontology Go:
cytosol
extracellular exosome
3',5'-cyclic-AMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
metal ion binding
cAMP catabolic process
cyclic nucleotide metabolic process
regulation of transcription, DNA-templated
signal transduction
Gene Ontology Biological Process:
cAMP catabolic process
cyclic nucleotide metabolic process
regulation of transcription, DNA-templated
signal transduction
Gene Ontology Molecular Function:
3',5'-cyclic-AMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
metal ion binding
Gene Ontology Cellular Component:
cytosol
extracellular exosome
Keywords:
3D-structure
Alternative splicing
Complete proteome
Hydrolase
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
cAMP

Publication

PubMed ID:
11738832 11371644 14702039 16572171 15489334 9618252 18691976 18669648 20068231 22673573 18983167