Names & Taxonomy
- Uniprot ID:
- O60568
- Entry Name:
- PLOD3_HUMAN
- Status:
- reviewed
- Protein Names:
- Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3)
- Gene Names:
- PLOD3
- Gene Names Primary:
- PLOD3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 738
- Sequence:
- MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRGGDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSAESFCWPEWGLAEQYPEVGTGKRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRIFQNLNGALDEVVLKFDRNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPEGGCGFCNQDRRTLPGGQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHNNEVFHEPHIADSWPQLQDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSLDADAVLTNLQTLRILIEENRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGDTLRMELPQRDVFSGSDTDPDMAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHLHPDLWQIFDNPVDWKEQYIHENYSRALEGEGIVEQPCPDVYWFPLLSEQMCDELVAEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTESLFPGYHTKARAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHEGLPTTWGTRYIMVSFVDP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Function
- Function:
- Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
- Catalytic Activity:
- L-lysine- + 2-oxoglutarate + O(2) = (2S,5R)-5-hydroxy-L-lysine- + succinate + CO(2).
- Cofactor:
- COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875; ; COFACTOR: Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
- Active Site:
- ACT_SITE 729 729
- Cross Reference Drug Bank:
- DB00139 DB00126
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
rough endoplasmic reticulum membrane
iron ion binding
L-ascorbic acid binding
procollagen galactosyltransferase activity
procollagen glucosyltransferase activity
procollagen-lysine 5-dioxygenase activity
basement membrane assembly
cellular protein modification process
cellular response to hormone stimulus
collagen fibril organization
endothelial cell morphogenesis
epidermis morphogenesis
extracellular matrix organization
in utero embryonic development
lung morphogenesis
neural tube development
protein localization
vasodilation - Gene Ontology Biological Process:
- basement membrane assembly
cellular protein modification process
cellular response to hormone stimulus
collagen fibril organization
endothelial cell morphogenesis
epidermis morphogenesis
extracellular matrix organization
in utero embryonic development
lung morphogenesis
neural tube development
protein localization
vasodilation - Gene Ontology Molecular Function:
- iron ion binding
L-ascorbic acid binding
procollagen galactosyltransferase activity
procollagen glucosyltransferase activity
procollagen-lysine 5-dioxygenase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
extracellular exosome
rough endoplasmic reticulum membrane - Keywords:
- Complete proteome
Dioxygenase
Disease mutation
Endoplasmic reticulum
Glycoprotein
Iron
Membrane
Metal-binding
Oxidoreductase
Polymorphism
Reference proteome
Signal
Vitamin C - Interacts With:
- Q5JST6; A2ABF9; Q96QF0; Q9BQY4