Names & Taxonomy
- Uniprot ID:
- O60547
- Entry Name:
- GMDS_HUMAN
- Status:
- reviewed
- Protein Names:
- GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)
- Gene Names:
- GMDS
- Gene Names Primary:
- GMDS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 372
- Sequence:
- MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVHADVELMRTNPNA
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
- Pathway:
- Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.
- Catalytic Activity:
- GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H(2)O.
- Cofactor:
- COFACTOR: Name=NADP(+); Xref=ChEBI:CHEBI:58349;
- Active Site:
- ACT_SITE 155 155
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
GDP-mannose 4,6-dehydratase activity
NADP+ binding
'de novo' GDP-L-fucose biosynthetic process
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
GDP-mannose metabolic process
Notch signaling pathway
post-translational protein modification
protein N-linked glycosylation via asparagine - Gene Ontology Biological Process:
- 'de novo' GDP-L-fucose biosynthetic process
cellular protein metabolic process
dolichol-linked oligosaccharide biosynthetic process
GDP-mannose metabolic process
Notch signaling pathway
post-translational protein modification
protein N-linked glycosylation via asparagine - Gene Ontology Molecular Function:
- GDP-mannose 4,6-dehydratase activity
NADP+ binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Lyase
NADP
Reference proteome - Interacts With:
- Q96HA8