Names & Taxonomy
- Uniprot ID:
- O60294
- Entry Name:
- TYW4_HUMAN
- Status:
- reviewed
- Protein Names:
- tRNA wybutosine-synthesizing protein 4 (tRNA yW-synthesizing protein 4) (EC 2.1.1.290) (EC 2.3.1.231) (Leucine carboxyl methyltransferase 2) (tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase) (tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase)
- Gene Names:
- LCMT2 KIAA0547 TYW4
- Gene Names Primary:
- LCMT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 686
- Sequence:
- MGPRSRERRAGAVQNTNDSSALSKRSLAARGYVQDPFAALLVPGAARRAPLIHRGYYVRARAVRHCVRAFLEQIGAPQAALRAQILSLGAGFDSLYFRLKTAGRLARAAVWEVDFPDVARRKAERIGETPELCALTGPFERGEPASALCFESADYCILGLDLRQLQRVEEALGAAGLDAASPTLLLAEAVLTYLEPESAAALIAWAAQRFPNALFVVYEQMRPQDAFGQFMLQHFRQLNSPLHGLERFPDVEAQRRRFLQAGWTACGAVDMNEFYHCFLPAEERRRVENIEPFDEFEEWHLKCAHYFILAASRGDTLSHTLVFPSSEAFPRVNPASPSGVFPASVVSSEGQVPNLKRYGHASVFLSPDVILSAGGFGEQEGRHCRVSQFHLLSRDCDSEWKGSQIGSCGTGVQWDGRLYHTMTRLSESRVLVLGGRLSPVSPALGVLQLHFFKSEDNNTEDLKVTITKAGRKDDSTLCCWRHSTTEVSCQNQEYLFVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSACTWQGGALIAGGLGASEEPLNSVLFLRPISCGFLWESVDIQPPITPRYSHTAHVLNGKLLLVGGIWIHSSSFPGVTVINLTTGLSSEYQIDTTYVPWPLMLHNHTSILLPEEQQLLLLGGGGNCFSFGTYFNPHTVTLDLSSLSAGQ
- Proteomes:
- UP000005640
Function
- Function:
- Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
- Pathway:
- tRNA modification; wybutosine-tRNA(Phe) biosynthesis.
- Catalytic Activity:
- S-adenosyl-L-methionine + 7-((3S)-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) = S-adenosyl-L-homocysteine + 7-((3S)-3-amino-3-(methoxycarbonyl)propyl)wyosine(37) in tRNA(Phe).; S-adenosyl-L-methionine + 7-((3S)-3-amino-3-(methoxycarbonyl)propyl)wyosine(37) in tRNA(Phe) + CO(2) = S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe).
- Cross Reference Drug Bank:
- DB00149
- Gene Ontology Go:
- cytoplasm
cytosol
S-adenosylmethionine-dependent methyltransferase activity
tRNA methyltransferase activity
gene expression
tRNA methylation
tRNA modification
tRNA processing
wybutosine biosynthetic process - Gene Ontology Biological Process:
- gene expression
tRNA methylation
tRNA modification
tRNA processing
wybutosine biosynthetic process - Gene Ontology Molecular Function:
- S-adenosylmethionine-dependent methyltransferase activity
tRNA methyltransferase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol - Keywords:
- Complete proteome
Methyltransferase
Polymorphism
Reference proteome
S-adenosyl-L-methionine
Transferase
tRNA processing