Names & Taxonomy
- Uniprot ID:
- O43868
- Entry Name:
- S28A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/nucleoside cotransporter 2 (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Sodium/purine nucleoside co-transporter) (SPNT) (Solute carrier family 28 member 2)
- Gene Names:
- SLC28A2 CNT2
- Gene Names Primary:
- SLC28A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 658
- Sequence:
- MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSRWPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVHSFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGICMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYTVAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTATETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDASSLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLATNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMVAEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLSSIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPNTSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by formycin B.
- Cross Reference Drug Bank:
- DB01033
- Gene Ontology Go:
- integral component of plasma membrane
membrane
plasma membrane
nucleoside:sodium symporter activity
purine nucleoside transmembrane transporter activity
nucleobase-containing compound metabolic process
purine nucleoside transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- nucleobase-containing compound metabolic process
purine nucleoside transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- nucleoside:sodium symporter activity
purine nucleoside transmembrane transporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Complete proteome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport