Names & Taxonomy
- Uniprot ID:
- O43776
- Entry Name:
- SYNC_HUMAN
- Status:
- reviewed
- Protein Names:
- Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (AsnRS)
- Gene Names:
- NARS
- Gene Names Primary:
- NARS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 548
- Sequence:
- MVLAELYVSDREGSDATGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKENERWNVISKSQLKNIKKMWHREQMKSESREKKEAEDSLRREKNLEEAKKITIKNDPSLPEPKCVKIGALEGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLADELCQCYNGVLLSTESSVAVYGMLNLTPKGKQAPGGHELSCDFWELIGLAPAGGADNLINEESDVDVQLNNRHMMIRGENMSKILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLPALGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTFDDLLNRLEDLVCDVVDRILKSPAGSIVHELNPNFQPPKRPFKRMNYSDAIVWLKEHDVKKEDGTFYEFGEDIPEAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDSRLTESVDVLMPNVGEIVGGSMRIFDSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRYHIRDVCLYPRFVQRCTP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Catalytic Activity:
- ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).
- Cross Reference Drug Bank:
- DB00174
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
mitochondrion
asparagine-tRNA ligase activity
ATP binding
nucleic acid binding
asparaginyl-tRNA aminoacylation
gene expression
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- asparaginyl-tRNA aminoacylation
gene expression
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- asparagine-tRNA ligase activity
ATP binding
nucleic acid binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
mitochondrion - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Complete proteome
Cytoplasm
Direct protein sequencing
Ligase
Nucleotide-binding
Phosphoprotein
Protein biosynthesis
Reference proteome