Names & Taxonomy

Uniprot ID:
O43772
Entry Name:
MCAT_HUMAN
Status:
reviewed
Protein Names:
Mitochondrial carnitine/acylcarnitine carrier protein (Carnitine/acylcarnitine translocase) (CAC) (Solute carrier family 25 member 20)
Gene Names:
SLC25A20 CAC CACT
Gene Names Primary:
SLC25A20
Organism:
Homo sapiens (Human)

Structure

Length:
301
Sequence:
MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLNWATPNL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion inner membrane; Multi-pass membrane protein.

Function

Function:
Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway.
Cross Reference Drug Bank:
DB00583
Gene Ontology Go:
cytoplasm
integral component of membrane
mitochondrial inner membrane
mitochondrion
structural constituent of ribosome
carnitine shuttle
cellular lipid metabolic process
small molecule metabolic process
translation
Gene Ontology Biological Process:
carnitine shuttle
cellular lipid metabolic process
small molecule metabolic process
translation
Gene Ontology Molecular Function:
structural constituent of ribosome
Gene Ontology Cellular Component:
cytoplasm
integral component of membrane
mitochondrial inner membrane
mitochondrion
Keywords:
Acetylation
Complete proteome
Disease mutation
Membrane
Mitochondrion
Mitochondrion inner membrane
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
9399886 9837782 14702039 15489334 21269460 24275569 25944712 12859414 15057979 15365988