Names & Taxonomy
- Uniprot ID:
- O43739
- Entry Name:
- CYH3_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytohesin-3 (ARF nucleotide-binding site opener 3) (Protein ARNO3) (General receptor of phosphoinositides 1) (Grp1) (PH, SEC7 and coiled-coil domain-containing protein 3)
- Gene Names:
- CYTH3 ARNO3 GRP1 PSCD3
- Gene Names Primary:
- CYTH3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 400
- Sequence:
- MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate.
Function
- Function:
- Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP.
- Gene Ontology Go:
- cytosol
extrinsic component of cytoplasmic side of plasma membrane
plasma membrane
ruffle
ARF guanyl-nucleotide exchange factor activity
phosphatidylinositol-3,4,5-trisphosphate binding
establishment of epithelial cell polarity
Golgi vesicle transport
positive regulation of cell adhesion
positive regulation of GTPase activity
regulation of ARF protein signal transduction - Gene Ontology Biological Process:
- establishment of epithelial cell polarity
Golgi vesicle transport
positive regulation of cell adhesion
positive regulation of GTPase activity
regulation of ARF protein signal transduction - Gene Ontology Molecular Function:
- ARF guanyl-nucleotide exchange factor activity
phosphatidylinositol-3,4,5-trisphosphate binding - Gene Ontology Cellular Component:
- cytosol
extrinsic component of cytoplasmic side of plasma membrane
plasma membrane
ruffle - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Coiled coil
Complete proteome
Cytoplasm
Guanine-nucleotide releasing factor
Lipid-binding
Membrane
Reference proteome - Interacts With:
- Q96HB5-4; Q969H4; Q8N0S2