Names & Taxonomy
- Uniprot ID:
- O43708
- Entry Name:
- MAAI_HUMAN
- Status:
- reviewed
- Protein Names:
- Maleylacetoacetate isomerase (MAAI) (EC 5.2.1.2) (GSTZ1-1) (Glutathione S-transferase zeta 1) (EC 2.5.1.18)
- Gene Names:
- GSTZ1 MAAI
- Gene Names Primary:
- GSTZ1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 216
- Sequence:
- MQAGKPILYSYFRSSCSWRVRIALALKGIDYKTVPINLIKDRGQQFSKDFQALNPMKQVPTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.
- Pathway:
- Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6.
- Catalytic Activity:
- 4-maleylacetoacetate = 4-fumarylacetoacetate.
- Cofactor:
- COFACTOR: Name=glutathione; Xref=ChEBI:CHEBI:57925; ; Note=Glutathione is required for the MAAI activity.;
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- cytosol
mitochondrion
glutathione peroxidase activity
glutathione transferase activity
maleylacetoacetate isomerase activity
protein homodimerization activity
cellular nitrogen compound metabolic process
cellular oxidant detoxification
glutathione derivative biosynthetic process
glutathione metabolic process
L-phenylalanine catabolic process
small molecule metabolic process
tyrosine catabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
cellular oxidant detoxification
glutathione derivative biosynthetic process
glutathione metabolic process
L-phenylalanine catabolic process
small molecule metabolic process
tyrosine catabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- glutathione peroxidase activity
glutathione transferase activity
maleylacetoacetate isomerase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytosol
mitochondrion - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Isomerase
Multifunctional enzyme
Phenylalanine catabolism
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Tyrosine catabolism - Interacts With:
- P16333