Names & Taxonomy

Uniprot ID:
O43526
Entry Name:
KCNQ2_HUMAN
Status:
reviewed
Protein Names:
Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2)
Gene Names:
KCNQ2
Gene Names Primary:
KCNQ2
Organism:
Homo sapiens (Human)

Structure

Length:
872
Sequence:
MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSPCRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.
Intramembrane:
INTRAMEM 265 285 Pore-forming; Name=Segment H5.

Function

Function:
Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.
Cross Reference Drug Bank:
DB00321 DB00586 DB04953 DB00939
Gene Ontology Go:
axon initial segment
node of Ranvier
plasma membrane
voltage-gated potassium channel complex
ankyrin binding
delayed rectifier potassium channel activity
potassium channel activity
voltage-gated potassium channel activity
axon guidance
nervous system development
potassium ion transport
synaptic transmission
Gene Ontology Biological Process:
axon guidance
nervous system development
potassium ion transport
synaptic transmission
Gene Ontology Molecular Function:
ankyrin binding
delayed rectifier potassium channel activity
potassium channel activity
voltage-gated potassium channel activity
Gene Ontology Cellular Component:
axon initial segment
node of Ranvier
plasma membrane
voltage-gated potassium channel complex
Keywords:
Alternative splicing
Complete proteome
Disease mutation
Epilepsy
Ion channel
Ion transport
Membrane
Mental retardation
Phosphoprotein
Polymorphism
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

Publication

PubMed ID:
9039501 9425895 9430594 9836639 9827540 9677360 11160379 11780052 15489334 9872318 10479678 11034315 10788442 10684873 10713961 10908292 10953053 10713399 10781098 14759258 16319223 10323247 11175290 11572947 14534157 12742592 15249611 17872363