Names & Taxonomy
- Uniprot ID:
- O43511
- Entry Name:
- S26A4_HUMAN
- Status:
- reviewed
- Protein Names:
- Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4)
- Gene Names:
- SLC26A4 PDS
- Gene Names Primary:
- SLC26A4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 780
- Sequence:
- MAAPGGRSEPPQLPEYSCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKCCSCSRKRAFGVLKTLVPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYFIFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLIASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIVSIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKILRFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDAVSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFLDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILYLQNQVKSQEGQGSILETITLIQDCKDTLELIETELTEEELDVQDEAMRTLAS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Sodium-independent transporter of chloride and iodide.
- Gene Ontology Go:
- apical plasma membrane
brush border membrane
extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane
anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
chloride transmembrane transporter activity
iodide transmembrane transporter activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity
bicarbonate transport
inorganic anion transport
ion transport
oxalate transport
regulation of intracellular pH
regulation of membrane potential
regulation of pH
regulation of protein localization
sensory perception of sound
sulfate transmembrane transport
sulfate transport
transmembrane transport - Gene Ontology Biological Process:
- bicarbonate transport
inorganic anion transport
ion transport
oxalate transport
regulation of intracellular pH
regulation of membrane potential
regulation of pH
regulation of protein localization
sensory perception of sound
sulfate transmembrane transport
sulfate transport
transmembrane transport - Gene Ontology Molecular Function:
- anion:anion antiporter activity
bicarbonate transmembrane transporter activity
chloride channel activity
chloride transmembrane transporter activity
iodide transmembrane transporter activity
oxalate transmembrane transporter activity
secondary active sulfate transmembrane transporter activity
sulfate transmembrane transporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
brush border membrane
extracellular exosome
integral component of membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Chloride
Complete proteome
Deafness
Disease mutation
Membrane
Non-syndromic deafness
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport