Names & Taxonomy
- Uniprot ID:
- O43490
- Entry Name:
- PROM1_HUMAN
- Status:
- reviewed
- Protein Names:
- Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133)
- Gene Names:
- PROM1 PROML1 MSTP061
- Gene Names Orf:
- MSTP061
- Gene Names Primary:
- PROM1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 865
- Sequence:
- MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVHIFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAGIILCCVLGLLFIILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVANHQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGGILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRSSLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQGYQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYIHRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGGVFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEYYLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELESLKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANSLPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASLDFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVDVFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLAKYYRRMDSEDVYDDVETIPMKNMENGNNGYHKDHVYGIHNPVMTSPSQH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
Function
- Function:
- May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).
- Gene Ontology Go:
- apical plasma membrane
cell surface
endoplasmic reticulum
endoplasmic reticulum-Golgi intermediate compartment
extracellular exosome
extracellular space
integral component of plasma membrane
intracellular membrane-bounded organelle
microvillus membrane
photoreceptor outer segment
photoreceptor outer segment membrane
plasma membrane
vesicle
actinin binding
cadherin binding
camera-type eye photoreceptor cell differentiation
glomerular parietal epithelial cell differentiation
glomerular visceral epithelial cell differentiation
photoreceptor cell maintenance
positive regulation of nephron tubule epithelial cell differentiation
retina layer formation
retina morphogenesis in camera-type eye - Gene Ontology Biological Process:
- camera-type eye photoreceptor cell differentiation
glomerular parietal epithelial cell differentiation
glomerular visceral epithelial cell differentiation
photoreceptor cell maintenance
positive regulation of nephron tubule epithelial cell differentiation
retina layer formation
retina morphogenesis in camera-type eye - Gene Ontology Molecular Function:
- actinin binding
cadherin binding - Gene Ontology Cellular Component:
- apical plasma membrane
cell surface
endoplasmic reticulum
endoplasmic reticulum-Golgi intermediate compartment
extracellular exosome
extracellular space
integral component of plasma membrane
intracellular membrane-bounded organelle
microvillus membrane
photoreceptor outer segment
photoreceptor outer segment membrane
plasma membrane
vesicle - Keywords:
- Acetylation
Alternative splicing
Cell membrane
Cell projection
Cilium
Complete proteome
Cone-rod dystrophy
Direct protein sequencing
Disease mutation
Endoplasmic reticulum
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Retinitis pigmentosa
Signal
Stargardt disease
Transmembrane
Transmembrane helix - Interacts With:
- Q8VHP6