Names & Taxonomy
- Uniprot ID:
- O43184
- Entry Name:
- ADA12_HUMAN
- Status:
- reviewed
- Protein Names:
- Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha)
- Gene Names:
- ADAM12 MLTN UNQ346/PRO545
- Gene Names Orf:
- UNQ346/PRO545
- Gene Names Primary:
- ADAM12
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 909
- Sequence:
- MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVPRSTHTAYIK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.; Isoform 3: Secreted
Function
- Function:
- Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 1 zinc ion per subunit.;
- Active Site:
- ACT_SITE 351 351
- Gene Ontology Go:
- extracellular region
integral component of membrane
mitochondrion
nucleoplasm
plasma membrane
metalloendopeptidase activity
metallopeptidase activity
SH3 domain binding
zinc ion binding
cell adhesion
epidermal growth factor receptor signaling pathway
myoblast fusion - Gene Ontology Biological Process:
- cell adhesion
epidermal growth factor receptor signaling pathway
myoblast fusion - Gene Ontology Molecular Function:
- metalloendopeptidase activity
metallopeptidase activity
SH3 domain binding
zinc ion binding - Gene Ontology Cellular Component:
- extracellular region
integral component of membrane
mitochondrion
nucleoplasm
plasma membrane - Keywords:
- Alternative splicing
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Phosphoprotein
Polymorphism
Protease
Reference proteome
SH3-binding
Secreted
Signal
Transmembrane
Transmembrane helix
Zinc
Zymogen - Interacts With:
- O95633