Names & Taxonomy

Uniprot ID:
O43184
Entry Name:
ADA12_HUMAN
Status:
reviewed
Protein Names:
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM 12) (EC 3.4.24.-) (Meltrin-alpha)
Gene Names:
ADAM12 MLTN UNQ346/PRO545
Gene Names Orf:
UNQ346/PRO545
Gene Names Primary:
ADAM12
Organism:
Homo sapiens (Human)

Structure

Length:
909
Sequence:
MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVPRSTHTAYIK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.; Isoform 3: Secreted

Function

Function:
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 1 zinc ion per subunit.;
Active Site:
ACT_SITE 351 351
Gene Ontology Go:
extracellular region
integral component of membrane
mitochondrion
nucleoplasm
plasma membrane
metalloendopeptidase activity
metallopeptidase activity
SH3 domain binding
zinc ion binding
cell adhesion
epidermal growth factor receptor signaling pathway
myoblast fusion
Gene Ontology Biological Process:
cell adhesion
epidermal growth factor receptor signaling pathway
myoblast fusion
Gene Ontology Molecular Function:
metalloendopeptidase activity
metallopeptidase activity
SH3 domain binding
zinc ion binding
Gene Ontology Cellular Component:
extracellular region
integral component of membrane
mitochondrion
nucleoplasm
plasma membrane
Keywords:
Alternative splicing
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Phosphoprotein
Polymorphism
Protease
Reference proteome
SH3-binding
Secreted
Signal
Transmembrane
Transmembrane helix
Zinc
Zymogen
Interacts With:
O95633

Publication

PubMed ID:
9417060 12975309 15164054 15489334 9642263 10831617 12615925 15574124 18621736 16959974 21618342