Names & Taxonomy

Uniprot ID:
O43174
Entry Name:
CP26A_HUMAN
Status:
reviewed
Protein Names:
Cytochrome P450 26A1 (EC 1.14.-.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome)
Gene Names:
CYP26A1 CYP26 P450RAI1
Gene Names Primary:
CYP26A1
Organism:
Homo sapiens (Human)

Structure

Length:
497
Sequence:
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Function

Function:
Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
Cofactor:
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
Cross Reference Drug Bank:
DB00459 DB01026 DB00162
Gene Ontology Go:
endoplasmic reticulum membrane
heme binding
iron ion binding
oxygen binding
retinoic acid 4-hydroxylase activity
retinoic acid binding
metabolic process
negative regulation of retinoic acid receptor signaling pathway
retinoic acid catabolic process
small molecule metabolic process
vitamin metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
metabolic process
negative regulation of retinoic acid receptor signaling pathway
retinoic acid catabolic process
small molecule metabolic process
vitamin metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
heme binding
iron ion binding
oxygen binding
retinoic acid 4-hydroxylase activity
retinoic acid binding
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
Keywords:
Alternative splicing
Complete proteome
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase
Reference proteome

Publication

PubMed ID:
9228017 9716180 14702039 15164054 9826557