Names & Taxonomy
- Uniprot ID:
- O43174
- Entry Name:
- CP26A_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome P450 26A1 (EC 1.14.-.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome)
- Gene Names:
- CYP26A1 CYP26 P450RAI1
- Gene Names Primary:
- CYP26A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 497
- Sequence:
- MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Function
- Function:
- Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18-hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB00459 DB01026 DB00162
- Gene Ontology Go:
- endoplasmic reticulum membrane
heme binding
iron ion binding
oxygen binding
retinoic acid 4-hydroxylase activity
retinoic acid binding
metabolic process
negative regulation of retinoic acid receptor signaling pathway
retinoic acid catabolic process
small molecule metabolic process
vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- metabolic process
negative regulation of retinoic acid receptor signaling pathway
retinoic acid catabolic process
small molecule metabolic process
vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- heme binding
iron ion binding
oxygen binding
retinoic acid 4-hydroxylase activity
retinoic acid binding - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
- Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase
Reference proteome