Names & Taxonomy
- Uniprot ID:
- O15554
- Entry Name:
- KCNN4_HUMAN
- Status:
- reviewed
- Protein Names:
- Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (SKCa 4) (SKCa4) (IKCa1) (IK1) (KCa3.1) (KCa4) (Putative Gardos channel)
- Gene Names:
- KCNN4 IK1 IKCA1 KCA4 SK4
- Gene Names Primary:
- KCNN4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 427
- Sequence:
- MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 241 261 Pore-forming; Name=Segment H5.
Function
- Function:
- Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614).
- Cross Reference Drug Bank:
- DB00257 DB00228 DB01159 DB01110 DB00721 DB00468
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
membrane raft
neuronal cell body
plasma membrane
voltage-gated potassium channel complex
calcium-activated potassium channel activity
Intermediate conductance calcium-activated potassium channel activity
protein phosphatase binding
small conductance calcium-activated potassium channel activity
calcium ion transport
cell volume homeostasis
defense response
immune system process
phospholipid translocation
positive regulation of protein secretion
positive regulation of T cell receptor signaling pathway
potassium ion export
potassium ion transport
saliva secretion
stabilization of membrane potential
synaptic transmission - Gene Ontology Biological Process:
- calcium ion transport
cell volume homeostasis
defense response
immune system process
phospholipid translocation
positive regulation of protein secretion
positive regulation of T cell receptor signaling pathway
potassium ion export
potassium ion transport
saliva secretion
stabilization of membrane potential
synaptic transmission - Gene Ontology Molecular Function:
- calcium-activated potassium channel activity
Intermediate conductance calcium-activated potassium channel activity
protein phosphatase binding
small conductance calcium-activated potassium channel activity - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
membrane raft
neuronal cell body
plasma membrane
voltage-gated potassium channel complex - Keywords:
- Calmodulin-binding
Cell membrane
Complete proteome
Disease mutation
Hereditary hemolytic anemia
Immunity
Ion channel
Ion transport
Membrane
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport